therapeutic 1,237 words KG: ent-gene-694200ea 2026-03-22
kind:therapeuticsection:therapeuticsstate:published
Contents

GBA Gene Therapy for Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-694200ea
DrugCompany
Migalastat (Galafold)Amicus
AmbroxolVarious
Venglustat (GZ161)Sanofi
TrialPhase
ambroxol-PDPhase II
GBA-PD Natural HistoryObservational
TargetApproach
AADCEnzyme replacement
GBAGene therapy/chaperone
LRRK2Kinase inhibitor
SNCAASO/siRNA
ApproachStatus
IGF1 PeptideResearch
IGF1 MimeticsPreclinical
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Smartphone-Detected Motor Variability Correction
Score: 0.56
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36

Related Analyses (30)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · completed
GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's D
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (30)

Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Genetic Risk Modifiers in DLB Phenotype
clinical · proposed · Score: 0.40
DLB Treatment Response Biomarkers — Predicting Cholinesteras
clinical · proposed · Score: 0.40
DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-694200ea data_in benchmark_ot_ad_answer_key:GBA
benchmark_ot_ad_answer_key:GBA data_in ent-gene-694200ea