therapeutic 1,335 words KG: ent-gene-95937963 2026-03-26
kind:therapeuticsection:therapeuticsstate:published
Contents

HSP70/HSP90 Modulators

🔬 Protein Info
Gene Symbolent-gene-95937963
Subcellular Localizationdifferent cellular compartments: cytosolic HSC70 (HSPA8), mitochondrial mtHSP70 (HSPA9), ER-resident BiP (HSPA5), and in
CompoundTarget
GeldanamycinAnsamycin
17-DMAG (Alvespimycin)Ansamycin
RadicicolMacrolide
PU-H71Purine
AT13387Synthetic
GeranylgeranylacetoneHSF1
ArimoclomolHSF1
CelastrolHSF1
17-DMAGHSP90/HSP70
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50
Membrane Cholesterol Gradient Modulators
Score: 0.52

Related Analyses (11)

What are the minimal structural requirements for HSP70/HSP90
drug discovery · completed
Do chaperones selectively recognize pathological vs physiolo
protein biochemistry · failed
Do tau-specific HSP90 conformational states exist that diffe
structural biology · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (3)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-95937963 data_in benchmark_ot_ad_answer_key:HSP70
benchmark_ot_ad_answer_key:HSP70 data_in ent-gene-95937963