| Gene Symbol | ent-gene-95937963 |
| Category | Disease-Modifying Therapy |
| Target | Hsp70 (HSPA1A, HSPA8), Hsp40 co-chaperones |
| Mechanism | Induce Hsp70 expression to enhance protein quality control and clearance of misfolded proteins |
| Development Stage | Preclinical to Phase I |
| Protein | Gene |
| Hsp70 (HSPA1A) | HSPA1A |
| Hsc70 (HSPA8) | HSPA8 |
| Grp78/BiP | HSPA5 |
| mtHsp70 (Grp75) | HSPA9 |
| Compound | Source |
| Arimoclomol | HSF1 co-activator |
| Celastrol | HSF1 activator |
| 17-DMAG | Hsp90 inhibitor |
| Geldanamycin derivatives | Hsp90 inhibitor |
| 2-phenylethynesulfonamide (PES) | Hsp70 |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |