| Gene Symbol | ent-gene-9f063e98 |
| Target Region | Rationale |
| Coding sequence | Disrupt translation initiation or elongation |
| Splice sites | Alter splicing to create non-functional transcripts |
| 3' UTR | Affect mRNA stability and localization |
| Target | LRRK2 mRNA |
| Company | Bristol Myers Squibb |
| Chemistry | 2'-O-methoxyethyl (2'-MOE) |
| Route | Intrathecal (spinal) injection |
| Phase | Discovery / Preclinical |
| NCT Number | NCT03976375 |
| Indication | Parkinson's disease |
| Aspect | LRRK2 Kinase Inhibitors |
| Mechanism | Enzymatic inhibition |
| Protein levels | Unchanged |
| Dosing | Oral (small molecule) |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |