| Gene Symbol | ent-gene-7b80a607 |
| Autophagy activation | Inhibition of mTORC1 de-represses ULK1 complex, initiating autophagosome formation |
| Protein synthesis reduction | Decreased phosphorylation of S6K1 and 4E-BP1 reduces mRNA translation |
| Metabolic reprogramming | Shift from anabolic to catabolic metabolism |
| Neuroinflammation modulation | Reduced microglial activation and inflammatory cytokine production[@gao2020] |
| [APP](/entities/app-protein)/PS1 mice | Rapamycin treatment reduced amyloid-beta plaque burden and improved cognitive function[@caccamo2010] |
| 3xTg-AD mice | Everolimus restored synaptic plasticity and memory deficits[@maiese2020] |
| In vitro | mTOR inhibitors reduced tau phosphorylation and aggregation[@wang2022] |
| MPTP parkinsonian mice | Autophagy induction protected against MPTP-induced neurotoxicity[@wu2019] |
| LRRK2 models | mTOR inhibition reduced LRRK2-associated neurotoxicity[@liu2021] |
| SOD1 G93A mice | Rapamycin delayed disease onset and extended survival[@zhang2019] |
| TDP-43 models | Autophagy activation reduced TDP-43 protein aggregates[@barmada2014] |
| NCT03391739 | Rapamycin for AD - completed 2022, results pending |
| NCT03732439 | Everolimus for PD - completed 2023, showed safety but limited efficacy |
| NCT03426761 | Sirolimus for ALS - completed 2021, no significant benefit observed[@pagan2022] |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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