| Gene Symbol | ent-gene-bd555192 |
| Chromosome | 2q22 |
| Function | These targets explain why NURR1 activation is crucial for maintaining dopaminergic neuron identity and function [@nurr2020] |
| Target Gene | Function |
| TH (Tyrosine Hydroxylase) | Rate-limiting enzyme in dopamine synthesis |
| AADC (Aromatic L-Amino Acid Decarboxylase) | Converts L-DOPA to dopamine |
| DAT (Dopamine Transporter) | Regulates dopamine reuptake |
| VMAT2 (Vesicular Monoamine Transporter 2) | Controls dopamine packaging into vesicles |
| PITX3 | Essential for dopaminergic neuron development and survival |
| ALDH1A1 | Protects against dopamine oxidation toxicity |
| BDNF (Brain-Derived Neurotrophic Factor) | Promotes neuron survival and plasticity |
| Compound | Developer |
| Clemastine | Various |
| Benzofuran derivatives | Academic |
| Dihexa | Academic |
| AAV-NURR1 | Gene therapy |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |