therapeutic 1,495 words KG: ent-gene-4e2430b7 2026-03-27
kind:therapeuticsection:therapeuticstopic:alzheimerstopic:parkinsonstopic:psptopic:cbstopic:alstopic:ftdtopic:hd
Contents

PP2A Activator Therapy

🔬 Protein Info
Gene Symbolent-gene-4e2430b7
Tau proteinAt sites including Thr181, Ser202/Thr205, Thr231, Ser262, and Ser396/Ser404
Alpha-synucleinAt Ser129, the major phosphorylation site associated with Lewy body formation@wang2014
TDP-43Phosphorylated TDP-43 in ALS and FTD
Mutant huntingtinPathological phosphorylation sites
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (27)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (18)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-4e2430b7 data_in benchmark_ot_ad_answer_key:PP2A
benchmark_ot_ad_answer_key:PP2A data_in ent-gene-4e2430b7