therapeutic 1,714 words KG: ent-gene-677b2317 2026-03-22
kind:therapeuticsection:therapeuticsstate:published
Contents

Sigma-1 Receptor Agonists for Neurodegenerative Diseases

🔬 Protein Info
Gene Symbolent-gene-677b2317
TargetSigma-1 Receptor (SIGMAR1)
MechanismChaperone modulation, calcium homeostasis
StatusClinical trials (Phase II/III)
Key DrugsBlarcamesine, Fluvoxamine, Donepezil+
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Vagal Afferent Microbial Signal Modulation
Score: 0.52
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
Vocal Cord Neuroplasticity Stimulation
Score: 0.50

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (9)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40
Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-677b2317 data_in benchmark_ot_ad_answer_key:SIGMA1
benchmark_ot_ad_answer_key:SIGMA1 data_in ent-gene-677b2317