| Gene Symbol | ent-gene-0a25b85c |
| PI3K/Akt Pathway | Promotes neuronal survival and inhibits apoptosis |
| MAPK/ERK Pathway | Regulates synaptic plasticity, memory formation, and neuronal differentiation |
| PLCγ Pathway | Modulates calcium signaling and neurotransmitter release |
| Alzheimer's Disease | Reduced TrkB expression and signaling contribute to synaptic loss and cognitive decline |
| Parkinson's Disease | Nigrostriatal dopaminergic neurons show impaired TrkB signaling |
| Huntington's Disease | Mutant huntingtin disrupts BDNF transport and TrkB signaling |
| BDNF mimetics | Peptide fragments that activate TrkB |
| Dimeric TrkB agonists | Enhanced potency through receptor dimerization |
| Anti-TrkB antibodies | Monoclonal antibodies targeting TrkB extracellular domain |
| Bispecific antibodies | TrkB x other targets (e.g., amyloid, tau) |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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