| Gene Symbol | ent-gene-b254988d |
| Therapeutic Effect | Mechanism |
| Enhanced ubiquitination | Preservation of ubiquitin on OMM proteins |
| Increased receptor recruitment | p62, OPTN, NDP52 more efficiently recruited |
| Improved mitophagy | More efficient clearance of damaged mitochondria |
| Neuronal protection | Reduced oxidative stress and apoptosis |
| Alpha-synuclein reduction | Improved mitophagy decreases aggregation[@wang2023] |
| Company | Compound |
| Denali Therapeutics | DNL309 |
| DepYmed | TH3289 |
| Bristol Myers Squibb | BMS-986467 |
| Roche | Compound 9 |
| Academic consortia | Various |
| Molecular weight | <500 Da |
| Brain penetration | B/P ratio >1 |
| Selectivity | >100x vs other DUBs |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |