therapeutic 659 words KG: ent-gene-a90f5952 2026-03-26
kind:therapeuticsection:therapeuticsstate:publishedtherapeutic-category:disease-modifyingdisease:parkinsons-diseasemechanism:retromer-trafficking
Contents

VPS35 Retromer Targeting Therapies

🔬 Protein Info
Gene Symbolent-gene-a90f5952
CompoundCompany
R55 (Retronoser)Van Andel Institute/Procter & Gamble
Small molecule retromer activatorsMultiple
CombinationRationale
Retromer activator + LRRK2 inhibitorComplementary trafficking and kinase targets
Retromer activator + GBA chaperonelysosomal function enhancement
Retromer activator + alpha-synuclein antibodyReduce aggregate formation and improve clearance
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.46
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.78
Phase-Separated Organelle Targeting
Score: 0.69
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.52

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-a90f5952 data_in benchmark_ot_ad_answer_key:VPS35
benchmark_ot_ad_answer_key:VPS35 data_in ent-gene-a90f5952