Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD pathogenesis? — Analysis

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Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD pathogenesis? — Analysis

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analysis Created: 2026-04-21T01:27:50 By: orchestra-ci Quality: 40% ✓ SciDEX ID: analysis-SDA-2026-04-16-gap-pubmed-20260

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Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD pathogenesis?

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The abstract suggests that Aβ-tau synergy could explain negative results from anti-Aβ trials, contradicting the expectation that targeting the presumed initiating pathology would be therapeutic. This contradiction has major implications for therapeutic strategy design. Gap type: contradiction Source paper: Synergy between amyloid-β and tau in Alzheimer's disease. (2020, Nature neuroscience, PMID:32778792)

Gap: gap-pubmed-20260410-180503-a7a03974

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Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD

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