Dopaminergic Ventral Tegmental-Striatal Circuit Protection

h-var-10237959a6

The dopaminergic ventral tegmental-striatal circuit protection hypothesis proposes that MAPT-encoded tau protein dysfunction specifically compromises dopaminergic neurotransmission through disrupted axonal transport and synaptic vesicle dynamics. Under normal conditions, tau protein facilitates the transport of tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and vesicular monoamine tran