Cholinergic Basal Forebrain-Hippocampal Circuit Protection

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## **Molecular Mechanism and Rationale** The cholinergic basal forebrain-hippocampal circuit protection hypothesis centers on the intricate molecular interplay between MAPT-encoded tau protein dysfunction and cholinergic neurotransmission. Under physiological conditions, tau protein stabilizes microtubules through its microtubule-binding domain, facilitating axonal transport of synaptic vesicles