Dual-Circuit Tau Vulnerability Cascade with Glial-Mediated Amplification

h-var-1906e102cf

## **Molecular Mechanism and Rationale** The dual-circuit tau vulnerability cascade with glial-mediated amplification represents a novel mechanistic framework explaining how MAPT-encoded tau pathology systematically dismantles critical brain circuits through sequential dysfunction of noradrenergic and cholinergic systems, with pathological amplification by neuroinflammatory processes. At the mole