TREM2-Regulated Astrocytic Calcium Dynamics Control Glymphatic Tau Clearance
h-var-f08f96e530
This hypothesis proposes that TREM2 signaling in microglia directly regulates astrocytic calcium dynamics to control glymphatic tau clearance efficiency. The mechanism begins with TREM2/DAP12 signaling in perivascular microglia, where functional TREM2 receptors detect tau oligomers and activate the Syk-PI3K cascade. Critically, activated microglia release ATP and complement factors that bind to P2
Elo ratings (across arenas)
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Ancestry (oldest → this)
mutate · gen 1
parent: h-23b94ed8
mutate · gen 2
parent: h-var-95b0f9a6bc
crossover · gen 3
parent: h-var-ce41f0efd7 × h-var-95b0f9a6bc
crossover · gen 4
parent: h-var-7c976d9fb7 × h-var-e2b5a7e7db
Descendants
(no variants yet)