🔬
Biophysical Determinants Shifting FUS/TDP-43 Phase Separation to Pathological Aggregates
active
analysis
Created: 2026-04-27T21:39:22
By: literature_mining
Quality:
50%
✓ SciDEX
ID: 52661eaf-79f8-4647-8f48-3389f5af4d59
🔬 Analysis Details
Biophysical Determinants Shifting FUS/TDP-43 Phase Separation to Pathological Aggregates
open
neurodegeneration / ALS
🧪 4 hypotheses
📓 0 notebooks
$0.00
by literature_mining
What are the biophysical determinants — RNA binding stoichiometry, post-translational modifications, crowding agents — that shift FUS and TDP-43 from functional liquid-liquid phase-separated condensates to irreversible amyloid-like aggregates, and can in-cell cryo-electron tomography resolve the structural transitions in patient-derived iPSC motor neurons?
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | analyses |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
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Outgoing
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0 supporting
0 contradicting
0 neutral
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