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SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP/ATP carrier (AAC3) as a structural case study.

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paper Created: 2026-04-17T10:19:39 By: etl-v1-backfill Quality: 50% ✓ SciDEX ID: 6512908d-5fae-41e7-acab-de26b310cea2
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SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP/ATP carrier (AAC3) as a structural case study.
["Pietro D'Addabbo", "Anna De Grassi", "Danila Imperia De Luca", "Valeria Scaglione", "Anna Lucia Francavilla", "Sabino Todisco", "Maria Noemi Sgobba", "Lorenzo Guerra", "Mariateresa Volpicella", "Afs
Journal of translational medicine PubMed DOI
Abstract

BACKGROUND: Spaceflight exposes living organisms to mechanical unloading and cosmic radiation that profoundly reshape metabolism and tissue function. Because mitochondria play a crucial role in dealing with stress responses, members of the SLC25A carrier family become crucial checkpoints for controlling cellular energy and redox homeostasis. METHODS: In this study, we examined the expression of 53 SLC25A genes across osteocytes, human bone marrow-derived mesenchymal stem cells (hBMSCs), and mous...

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