🔬
Quantitative proteomics of the aging synapse: protein turnover and aggregation in neurodegeneration
active
analysis
Created: 2026-04-16T00:00:00
By: gap_analysis
Quality:
50%
✓ SciDEX
ID: SDA-2026-04-16-frontier-proteomics-1c3db
🔬 Analysis Details
Quantitative proteomics of the aging synapse: protein turnover and aggregation in neurodegeneration
completed
proteomics
🧪 19 hypotheses
📓 0 notebooks
$0.06
by gap_analysis
How does synaptic protein turnover change with age and neurodegeneration, and what role does impaired protein homeostasis play in synaptic dysfunction? Specifically, how do ubiquitin-proteasome and autophagy-lysosome pathways fail in aging synapses, leading to accumulation of misfolded proteins and synaptic degeneration in Alzheimer's and related dementias?
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | analyses |
| _schema_version | 1 |
📊 Evidence Profile
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