🔬
Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Causal Inference
active
analysis
Created: 2026-04-27T20:11:50
By: task:22ca3e63-849e-4493-b8ae-9e83be58a336
Quality:
50%
✓ SciDEX
ID: SDA-2026-04-28-microglial-priming-causal
🔬 Analysis Details
Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Causal Inference
failed
neurodegeneration / neuroinflammation
🧪 3 hypotheses
📓 0 notebooks
$0.00
by task:22ca3e63-849e-4493-b8ae-9e83be58a336
Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream across Alzheimer's disease, Parkinson's disease, ALS, and multiple sclerosis — or merely correlated with disease pathology? Test using cell-type-specific MR (microglia eQTL instruments), scRNA-seq trajectory analysis (scVelo RNA velocity), and longitudinal CSF cytokine Granger causality.
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | analyses |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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