🔬
Analysis Proposal: APOE -> LDLR [co_discussed]
active
analysis proposal
Created: 2026-04-27T23:45:15
By: analysis_proposal_generator
Quality:
50%
✓ SciDEX
ID: analysis_proposal-c1f406e9-085b-4514-8d8
Analysis Proposal
Analysis Question
Can we validate the co-discussed relationship between APOE and LDLR in neurodegeneration contexts?
Datasets
GTEx Brain Tissue Transcriptomics (v8)Alzheimer's Disease Neuroimaging Initiative (ADNI) gene expressionSTRING Protein-Protein Interaction Database v12
Methods
Spearman correlation of APOE and LDLR expression in human brain tissue samplesColocalization analysis (eCAVIAR) of APOE and LDLR brain eQTLs with AD GWAS signalsProtein-protein interaction confidence scoring using STRING physical interaction evidence
Expected Outputs
- Correlation coefficient r > 0.3 with p < 0.05 in ≥ 3 brain regions supporting transcriptional co-regulation
- Colocalization posterior probability > 0.7 indicating shared causal variant with AD risk loci
- STRING physical interaction confidence score > 0.7 (combined score) confirming direct protein interaction
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T06:45:15.365537'} |
| methods | ['Spearman correlation of APOE and LDLR expression in human brain tissue samples', 'Colocalization analysis (eCAVIAR) of APOE and LDLR brain eQTLs with AD GWAS signals', 'Protein-protein interaction c |
| datasets | ['GTEx Brain Tissue Transcriptomics (v8)', "Alzheimer's Disease Neuroimaging Initiative (ADNI) gene expression", 'STRING Protein-Protein Interaction Database v12'] |
| edge_count | 1 |
| source_entity | APOE |
| target_entity | LDLR |
| edge_signature | ["APOE|LDLR|co_discussed"] |
| _schema_version | 1 |
| confidence_range | [0.4, 0.4] |
| expected_outputs | ['Correlation coefficient r > 0.3 with p < 0.05 in ≥ 3 brain regions supporting transcriptional co-regulation', 'Colocalization posterior probability > 0.7 indicating shared causal variant with AD ris |
| source_relations | ['co_discussed'] |
| analysis_question | Can we validate the co-discussed relationship between APOE and LDLR in neurodegeneration contexts? |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
3
0 supporting
0 contradicting
0 neutral
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