gene

LDLR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDLR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1227Connections

15Hypotheses

7Analyses

50Outgoing

50Incoming

0Experiments

12Debates

Summary

LDLR is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with ADH, ALS, ALZHEIMER'S DISEASE. Connected to 499 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	LDLR
Chromosome	19p13.2
Protein Type	Receptor
Target Class	Receptor
Function	LDL Binding: Extracellular domain binds circulating LDL (containing cholesterol and triglycerides)
Mechanism of Action	Upregulation through PCSK9 inhibition or direct receptor modulation
Druggability	High (0.75)
Clinical Stage	Approved
Amino Acids	860 aa
Exons	18
Pathways	Cholesterol, Cholesterol Metabolism, Complement, EGFR_signaling, Endocytosis
UniProt ID	H0YMD1
Ensembl ID	ENSG00000130164
GeneCards	LDLR
Human Protein Atlas	LDLR
Associated Diseases	ADH, Aging, Als, Alzheimer
Known Drugs/Compounds	25-Hydroxycholesterol, lipid_lowering_medications, statins
Interactions	AB, ABCA1, abca2, ABCA2, ACETYL-COA, Actin
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	FcRn Transport Bypass Strategy LRP1-Mediated Endosomal Escape Enhancement Strateg LDLR-Targeted Anti-Inflammatory Antibody Delivery (+9 more)
KG Connections	1226 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LDLR — AlphaFold H0YMD1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LDLR["LDLR"] -->|"interacts"| ABCA1["ABCA1"]
    LDLR["LDLR"] -->|"interacts"| SREBF2["SREBF2"]
    LDLR["LDLR"] -->|"studied in"| neurodegeneration["neurodegeneration"]
    LDLR["LDLR"] -->|"associated"| neurodegeneration_1["neurodegeneration"]
    LDLR["LDLR"] -->|"interacts"| APOE["APOE"]
    LDLR["LDLR"] -->|"interacts"| LRP1["LRP1"]
    ABCA1_2["ABCA1"] -->|"interacts"| LDLR["LDLR"]
    SREBF2_3["SREBF2"] -->|"interacts"| LDLR["LDLR"]
    APOE_4["APOE"] -->|"interacts"| LDLR["LDLR"]
    LRP1_5["LRP1"] -->|"interacts"| LDLR["LDLR"]
    style LDLR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (758)

Target	Relation	Type	Str
LDLR	encodes	protein	0.00
LDL	regulates	protein	0.97
Autosomal Dominant Hypercholesterolemia	risk_factor_for	disease	0.95
Familial Hypercholesterolemia	associated_with	disease	0.95
familial hypercholesterolemia	causes	disease	0.95
cardiovascular disease	associated_with	disease	0.90
Lipid Metabolism	regulates	pathway	0.90
cholesterol metabolism	participates_in	pathway	0.90
LDL Cholesterol Metabolism	involved_in	process	0.90
Variant Classification	involved_in	process	0.90
Tau Pathology	inhibits	phenotype	0.90
Cholesterol Transport	involved_in	process	0.90
LDL cholesterol	regulates	phenotype	0.90
MICROGLIA	associated_with	cell_type	0.90
lipid metabolism	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
Brain Apoe Levels	downregulates	biomarker	0.90
APOE	activates	gene	0.90
Pulmonary Arterial Hypertension	implicated_in	disease	0.85
LIPID METABOLISM	regulates	entity	0.85
Pulmonary Arterial Hypertension	involved_in	disease	0.85
Als	inhibits	disease	0.85
Neurodegeneration	protects_against	process	0.85
Microglial Activation	inhibits	process	0.85
Interleukin-17C	interacts_with	protein	0.80
Vascular Remodeling	contributes_to	process	0.80
Microglial Immunometabolism	modulates	process	0.80
coronary artery disease	associated_with	disease	0.80
Endothelial Dysfunction	contributes_to	phenotype	0.80
Cholesterol	regulates	pathway	0.80
cholesterol	regulates	protein	0.80
hypercholesterolemia	associated_with	disease	0.79
FAMILIAL_HYPERCHOLESTEROLEMIA	associated_with	disease	0.76
Atherosclerosis	activates	disease	0.75
Neurodegeneration	inhibits	disease	0.75
Reactive Astrocyte Activation	inhibits	process	0.75
Oligodendrocyte Progenitor Cells	modulates	cell_type	0.75
Als	associated_with	disease	0.75
Inflammatory Pathway	interacts_with	pathway	0.75
Als	activates	disease	0.75
Oligodendrocyte Progenitor Cell Expansion	upregulates	process	0.75
neurodegeneration	inhibits	phenotype	0.75
Myelin Integrity	protects_against	phenotype	0.75
OXIDATIVE STRESS	regulates	entity	0.75
Atherosclerosis	regulates	disease	0.75
Cardiovascular	activates	disease	0.75
Aging	associated_with	disease	0.75
Cardiovascular	regulates	disease	0.75
cholesterol_metabolism	regulates	pathway	0.72
cholesterol_homeostasis	regulates	pathway	0.72

Incoming (469)

Source	Relation	Type	Str
LDLR	encodes	gene	0.00
TDP-43	binds	protein	1.00
PCSK9	inhibits	protein	0.95
TNF	upregulates	protein	0.90
h-9d29bfe5	targets	hypothesis	0.90
h-64d92165	targets_gene	hypothesis	0.90
statins	activates	drug	0.90
h-9d16afa0	targets	hypothesis	0.90
h-b948c32c	targets	hypothesis	0.90
MAFF	regulates	protein	0.90
APOE	associated_with	gene	0.90
h-a87702b6	targets_gene	hypothesis	0.90
GOLIATH	inhibits	protein	0.85
APOE	binds_receptor	gene	0.85
SREBF1	regulates	protein	0.85
BACH1	inhibits	protein	0.85
RNF130	inhibits	protein	0.85
IDOL	inhibits	protein	0.85
25-Hydroxycholesterol	modulates	compound	0.85
NTS	associated_with	gene	0.80
CSF2	associated_with	gene	0.80
APOE3	binds	protein	0.80
BMP1	modifies	protein	0.80
γ-secretase	modifies	protein	0.80
MT1-MMP	modifies	protein	0.80
EGFR	interacts_with	gene	0.80
ASGR1	regulates	protein	0.80
TMEM55B	regulates	protein	0.80
APOE4	binds	protein	0.80
inflammation	inhibits	phenotype	0.80
CCR9	associated_with	gene	0.80
APOE2	binds_weakly	protein	0.80
IL13RA1	associated_with	gene	0.80
IDE	regulates	gene	0.70
CREB	regulates	gene	0.70
BMP	inhibits	gene	0.70
GPX4	transports	gene	0.70
APOE	targets	gene	0.70
ABCA1	targets	gene	0.70
CD2AP	activates	gene	0.70
ABCA1	protects_against	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
GFAP	disrupts	gene	0.70
CHAT	mediates	gene	0.70
APOE	expressed_in	gene	0.70
ABCA1	expressed_in	gene	0.70
CHOLESTEROL	causes	phenotype	0.70
EGFR	activates	gene	0.70
NEURODEGENERATION	inhibits	gene	0.70
LDL	activates	gene	0.70

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LDLR Ligand-Binding Domain A Fusion for Receptor-Mediated Tr	0.650	neurodegeneration	Blood-brain barrier antibody transport m
APOE4 preferentially signals through LRP1 over LDLR, alterin	0.610	neuroscience	APOE4-driven lipid metabolism dysregulat
FcRn Transport Bypass Strategy	0.585	neuropharmacology	What is the actual quantitative contribu
LRP1-Mediated Endosomal Escape Enhancement Strategy	0.518	neuropharmacology	What is the actual quantitative contribu
LDLR-Targeted Anti-Inflammatory Antibody Delivery for Neuroi	0.498	neuropharmacology	What is the actual quantitative contribu

RAGE-Mediated Transcytotic Pump Enhancement Strategy	0.380	neuropharmacology	What is the actual quantitative contribu
LDLR-Primed LRP1 Transcytosis with Endosomal Liberation Stra	0.380	neuropharmacology	What is the actual quantitative contribu
LDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Es	0.380	neuropharmacology	What is the actual quantitative contribu
LDLR-Mediated Neuroinflammation Modulation Strategy	0.380	neuropharmacology	What is the actual quantitative contribu
LDLR-Mediated Lipid Carrier Neurotherapeutic Delivery	0.380	neuropharmacology	What is the actual quantitative contribu
LDLR-Mediated Reverse Cholesterol Transport Modulation for C	0.380	neuropharmacology	What is the actual quantitative contribu
Poorly lipidated APOE4 particles are preferentially routed t	0.340	molecular-biology	Does APOE4's reduced lipid-binding direc
LDLR-Mediated Neurosteroid Precursor Delivery Strategy	0.000	neuropharmacology	What is the actual quantitative contribu
GLUT1-Mediated Carrier-Conjugate Delivery Strategy	0.000	neuropharmacology	What is the actual quantitative contribu
LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Stra	0.000	neuropharmacology	What is the actual quantitative contribu