gene

LDLR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDLR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1201Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

LDLR is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with ADH, ALS, ALZHEIMER'S DISEASE. Connected to 499 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LDLR
Chromosome	19p13.2
Protein Type	Receptor
Target Class	Receptor
Function	LDL Binding: Extracellular domain binds circulating LDL (containing cholesterol and triglycerides)
Mechanism of Action	Upregulation through PCSK9 inhibition or direct receptor modulation
Druggability	High (0.75)
Clinical Stage	Approved
Amino Acids	860 aa
Exons	18
Pathways	Cholesterol, Cholesterol Metabolism, Complement, EGFR_signaling, Endocytosis
UniProt ID	H0YMD1
Ensembl ID	ENSG00000130164
GeneCards	LDLR
Human Protein Atlas	LDLR
Associated Diseases	ADH, ALS, ATHEROSCLEROSIS, Aging, Alzheimer
Known Drugs/Compounds	lipid_lowering_medications, statins, 25-Hydroxycholesterol
Interactions	APOE, LRP1, ABCA1, SREBF2, EGF, EGFR
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	FcRn Transport Bypass Strategy
KG Connections	1201 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LDLR — AlphaFold H0YMD1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LDLR["LDLR"] -->|"interacts"| ABCA1["ABCA1"]
    LDLR["LDLR"] -->|"interacts"| SREBF2["SREBF2"]
    LDLR["LDLR"] -->|"studied in"| neurodegeneration["neurodegeneration"]
    LDLR["LDLR"] -->|"associated"| neurodegeneration_1["neurodegeneration"]
    LDLR["LDLR"] -->|"interacts"| APOE["APOE"]
    LDLR["LDLR"] -->|"interacts"| LRP1["LRP1"]
    ABCA1_2["ABCA1"] -->|"interacts"| LDLR["LDLR"]
    SREBF2_3["SREBF2"] -->|"interacts"| LDLR["LDLR"]
    APOE_4["APOE"] -->|"interacts"| LDLR["LDLR"]
    LRP1_5["LRP1"] -->|"interacts"| LDLR["LDLR"]
    style LDLR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (744)

Target	Relation	Type	Str
LDL	regulates	protein	0.97
familial hypercholesterolemia	causes	disease	0.95
Autosomal Dominant Hypercholesterolemia	risk_factor_for	disease	0.95
Familial Hypercholesterolemia	associated_with	disease	0.95
LDL cholesterol	regulates	phenotype	0.90
cardiovascular disease	contributes_to	disease	0.90
cholesterol metabolism	participates_in	pathway	0.90
LDL Cholesterol Metabolism	involved_in	process	0.90
Variant Classification	involved_in	process	0.90
Tau Pathology	suppresses	phenotype	0.90
Brain Apoe Levels	downregulates	biomarker	0.90
Cholesterol Transport	involved_in	process	0.90
lipid metabolism	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
MICROGLIA	regulates_activation	cell_type	0.90
Lipid Metabolism	regulates	pathway	0.90
APOE	activates	gene	0.90
Tau Pathology	inhibits	phenotype	0.85
Pulmonary Arterial Hypertension	involved_in	disease	0.85
Microglial Activation	suppresses	process	0.85
Pulmonary Arterial Hypertension	implicated_in	disease	0.85
Als	inhibits	disease	0.85
Neurodegeneration	protects_against	process	0.85
LIPID METABOLISM	regulates	entity	0.85
coronary artery disease	associated_with	disease	0.80
Microglial Activation	inhibits	process	0.80
Microglial Immunometabolism	modulates	process	0.80
Endothelial Dysfunction	contributes_to	phenotype	0.80
Vascular Remodeling	contributes_to	process	0.80
Interleukin-17C	interacts_with	protein	0.80
Cholesterol	regulates	pathway	0.80
hypercholesterolemia	associated_with	disease	0.79
FAMILIAL_HYPERCHOLESTEROLEMIA	associated_with	disease	0.76
Oligodendrocyte Progenitor Cell Expansion	upregulates	process	0.75
Myelin Integrity	protects_against	phenotype	0.75
Inflammatory Pathway	interacts_with	pathway	0.75
Oligodendrocyte Progenitor Cells	modulates	cell_type	0.75
Reactive Astrocyte Activation	suppresses	process	0.75
Als	activates	disease	0.75
Aging	associated_with	disease	0.75
Atherosclerosis	regulates	disease	0.75
Cardiovascular	regulates	disease	0.75
Neurodegeneration	inhibits	disease	0.75
Als	associated_with	disease	0.75
Atherosclerosis	activates	disease	0.75
Cardiovascular	activates	disease	0.75
OXIDATIVE STRESS	regulates	entity	0.75
cholesterol_homeostasis	regulates	pathway	0.72
cholesterol	regulates	protein	0.72
apoE_protein	regulates	protein	0.72

Incoming (457)

Source	Relation	Type	Str
TDP-43	binds	protein	1.00
PCSK9	inhibits	protein	0.95
statins	activates	drug	0.90
MAFF	regulates	protein	0.90
TNF	upregulates	protein	0.90
APOE	co_mentioned_with	gene	0.90
h-b948c32c	targets_gene	hypothesis	0.90
h-9d29bfe5	targets_gene	hypothesis	0.90
h-a87702b6	targets_gene	hypothesis	0.90
h-64d92165	targets_gene	hypothesis	0.90
h-9d16afa0	targets_gene	hypothesis	0.90
IDOL	inhibits	protein	0.85
GOLIATH	inhibits	protein	0.85
RNF130	inhibits	protein	0.85
BACH1	inhibits	protein	0.85
SREBF1	regulates	protein	0.85
25-Hydroxycholesterol	modulates	compound	0.85
ASGR1	regulates	protein	0.80
MT1-MMP	modifies	protein	0.80
BMP1	modifies	protein	0.80
γ-secretase	modifies	protein	0.80
h-b948c32c	targets	hypothesis	0.80
h-9d29bfe5	targets	hypothesis	0.80
TMEM55B	regulates	protein	0.80
EGFR	interacts_with	gene	0.80
CSF2	correlates_with	gene	0.80
NTS	correlates_with	gene	0.80
APOE2	binds_weakly	protein	0.80
APOE4	binds	protein	0.80
inflammation	inhibits	phenotype	0.80
CCR9	correlates_with	gene	0.80
IL13RA1	correlates_with	gene	0.80
APOE3	binds	protein	0.80
EGFR	activates	gene	0.70
TAU	inhibits	gene	0.70
APOE	produces	gene	0.70
APOE	destabilizes	gene	0.70
lipApoE2	interacts_with	protein	0.70
NEURODEGENERATION	inhibits	gene	0.70
LDL	activates	gene	0.70
CHOLESTEROL	destabilizes	phenotype	0.70
CHOLESTEROL	causes	phenotype	0.70
ABCA1	interacts_with	gene	0.68
SREBF2	interacts_with	gene	0.68
AQP4	associated_with	gene	0.65
APOE2	interacts_with	gene	0.65
APOE	modifies	gene	0.65
TDP-43	causes	gene	0.65
ATHEROSCLEROSIS	reduces	disease	0.65
APOE3	interacts_with	gene	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FcRn Transport Bypass Strategy	0.480	neuropharmacology	What is the actual quantitative contribu

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Decreased lipidated ApoE-receptor interactions confer protection against pathoge [PMID:39532095]	Guo JL, Braun D, Fitzgerald GA, Hsieh YT	Cell	2025
mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative li [PMID:40972529]	Shin S, Han MJ, Patel I, Welsh AM, Sverd	Mol Cell	2025
GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcifica [PMID:36923537]	Zheng G, Zhao Y, Li Z, Hua Y, Zhang J, M	Theranostics	2023
Delivery of low-density lipoprotein from endocytic carriers to mitochondria supp [PMID:37277481]	Zhou YX, Wei J, Deng G, Hu A, Sun PY et	Nat Cell Biol	2023
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022
Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesi [PMID:33176118]	Chen Y, Strickland MR, Soranno A, Holtzm	Neuron	2021
Evolution of blood-brain barrier in brain diseases and related systemic nanoscal [PMID:34522589]	Han L, Jiang C	Acta Pharm Sin B	2021
Materno-fetal cholesterol transport during pregnancy. [PMID:32369555]	Kallol S, Albrecht C	Biochem Soc Trans	2020
News on the molecular regulation and function of hepatic low-density lipoprotein [PMID:28301372]	van de Sluis B, Wijers M, Herz J	Curr Opin Lipidol	2017
Functions of lipoprotein receptors in neurons. [PMID:14657206]	Beffert U, Stolt PC, Herz J	J Lipid Res	2004

LDLR

Understanding Entity Pages

Summary

Wiki Pages (21)

LDLR Gene

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Therapeutics

Multiple System Atrophy

coq10-neurodegeneration

Pathway Diagram

Outgoing (744)

Incoming (457)

Targeting Hypotheses (1)

Mentioning Analyses (3)

CRISPR-based therapeutic approaches for neurodegenerative diseases

Blood-brain barrier transport mechanisms for antibody therapeutics

Lipid raft composition changes in synaptic neurodegeneration

Related Papers (10)

LDLR

Understanding Entity Pages

Summary

Wiki Pages (21)

LDLR Gene

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Therapeutics

Multiple System Atrophy

coq10-neurodegeneration

Growth Factor Therapies

CBS/PSP Clinical Trials Guide

Blood-Brain Barrier Dysfunction in Neurodegeneration

APOC4 — Apolipoprotein C-IV

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Blood-Brain Barrier Biology and Crossing Strategies

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

Splice-Modulating Therapies for Neurodegeneration

vitamin-d-therapy-neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Mediterranean and MIND Diets for Neurodegeneration

creatine-supplementation-neurodegeneration

Pathway Diagram

Outgoing (744)

Incoming (457)

Targeting Hypotheses (1)

Mentioning Analyses (3)

CRISPR-based therapeutic approaches for neurodegenerative diseases

Blood-brain barrier transport mechanisms for antibody therapeutics

Lipid raft composition changes in synaptic neurodegeneration

Related Papers (10)