🧫
PACAP agonist rescue experiment in sleep-deprived mice
active
experiment
Created: 2026-04-10T22:36:30
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-0a38c5d4-0c9a-4713-92fc-34aaff521153
🧫 Experiment Protocol
Exploratorysleep deprivation-induced synaptic dysfunctionPACAPmPFC brain slices from sleep-deprived miceproposed
Brain slices from sleep-deprived mice were perfused with a PACAP agonist to test whether PACAP activation could rescue LTP deficits observed in the model. This experiment was designed to validate the specific role of PACAP signaling in mediating the synaptic plasticity improvements and to demonstrate that PACAP pathway activation is sufficient to restore normal synaptic function even in the context of sleep deprivation.
PRIMARY OUTCOME
LTP rescue in sleep-deprived tissue
EXPECTED OUTCOMES
PACAP agonist would restore normal LTP in sleep-deprived brain tissue
SUCCESS CRITERIA
Significant improvement in LTP amplitude following PACAP agonist treatment
PROTOCOL
Brain slice preparation from sleep-deprived mice, PACAP agonist perfusion, LTP recordings
Source: PMID 41525914 ↗
🧫 Experiment Extras
PATHWAY
PACAP signaling pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.