🧫
Microtubule domain analysis in adult axons
active
experiment
Created: 2026-04-06T12:32:06
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-32576dcf-a6c7-4ff9-b7b8-37903a89693e
🧫 Experiment Protocol
ExploratoryMAPTadult rodent axonsproposed
Confirmation study of previous findings showing that individual microtubules in axons consist of labile and stable domains, and that tau depletion results in selective shortening and partial stabilization of the labile domain. This experiment extended previous work from juvenile rodent neurons to adult axons to validate the generalizability of the microtubule domain organization findings.
PRIMARY OUTCOME
microtubule domain organization
EXPECTED OUTCOMES
Confirmation that adult axons show similar microtubule domain organization as juvenile neurons
SUCCESS CRITERIA
Detection of distinct labile and stable domains on microtubules in adult axons
PROTOCOL
Analysis of microtubule labile and stable domains in adult axons, tau depletion experiments
LINKED HYPOTHESES
h-23b94ed8· Locus Coeruleus-Hippocampal Circuit Protectionh-var-f687d4593b· Cholinergic Basal Forebrain-Hippocampal Circuit Protectionh-var-bc4357c8c5· Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectionh-var-8412ce00a4· Dual-Circuit Tau Vulnerability Cascadeh-var-95b0f9a6bc· Glymphatic-Mediated Tau Clearance Dysfunction
Source: PMID 40040809 ↗
🧫 Experiment Extras
PATHWAY
microtubule dynamics
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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