🧫
Inhibition of transmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor, demonstrating this vulnerable subtype drives early motor symptoms.
active
experiment
Created: 2026-04-27T23:19:02
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-3c250dfe45e8
🧫 Experiment Protocol
Animal ModelParkinson's diseaseANXA1mouseextracted
Functional experiment using genetic/inhibition approach; demonstrates sufficiency of Anxa1+ DANs for motor symptoms
PRIMARY OUTCOME
Inhibition of transmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor, demonstrating this vulnerable subtype drives early motor symptoms.
Source: pmid_39763754
🧫 Experiment Extras
PATHWAY
dopaminergic signaling
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.