🧫
Differential GWAS of schizophrenia vs PTSD
active
experiment
Created: 2026-04-11T00:50:49
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-418bb59a-ec31-4ef0-a39e-4592928aea4b
🧫 Experiment Protocol
Exploratoryschizophrenia, post-traumatic stress disorderMAPT, CRHR1human patients - European ancestry and trans-ancestry populationsproposed
A differential genome-wide association study comparing the genetic architectures of schizophrenia (SCZ) and post-traumatic stress disorder (PTSD) using publicly available GWAS summary statistics from the Psychiatric Genomics Consortium (PGC). The study identified four independent loci with genome-wide significant differential associations between SCZ and PTSD in European ancestry individuals. These loci showed genome-wide significant associations with SCZ and nominal associations with PTSD but with opposite directions of effect. The analysis included trans-ancestry meta-analysis validation and focused particularly on the rs62062288 variant at the MAPT/CRHR1 locus on chromosome 17q21.31, which showed a risk effect for PTSD and protective effect for SCZ.
PRIMARY OUTCOME
differential genetic associations between SCZ and PTSD
EXPECTED OUTCOMES
Identification of genetic loci with opposing effects on SCZ and PTSD risk, with validation of brain-region-specific regulatory effects on target genes
SUCCESS CRITERIA
genome-wide significance threshold P < 5 × 10^-8 for differential associations
PROTOCOL
Differential GWAS analysis using PGC summary statistics, followed by trans-ancestry meta-analysis validation and GTEx expression quantitative trait locus (eQTL) analysis to examine regulatory effects on gene expression in brain tissues
LINKED HYPOTHESES
h-var-bc4357c8c5· Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectionh-23b94ed8· Locus Coeruleus-Hippocampal Circuit Protectionh-var-f687d4593b· Cholinergic Basal Forebrain-Hippocampal Circuit Protectionh-var-8412ce00a4· Dual-Circuit Tau Vulnerability Cascadeh-var-95b0f9a6bc· Glymphatic-Mediated Tau Clearance Dysfunction
Source: PMID 41767305 ↗
🧫 Experiment Extras
PATHWAY
neurodevelopmental pathways, stress response, tau protein regulation, corticotropin-releasing hormone signaling
MARKET PRICE
$0.50
STATUS
proposed
Prediction Markets (1 direct, 0 via hypothesis — 1 total)
Glymphatic-Mediated Tau Clearance DysfunctionYES 72% · Liq $100 · resolved▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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