Exploratory experiment designed to discover new patterns targeting MAPT, CRHR1 in human patients - European ancestry and trans-ancestry populations. Primary outcome: differential genetic associations between SCZ and PTSD
A differential genome-wide association study comparing the genetic architectures of schizophrenia (SCZ) and post-traumatic stress disorder (PTSD) using publicly available GWAS summary statistics from the Psychiatric Genomics Consortium (PGC). The study identified four independent loci with genome-wide significant differential associations between SCZ and PTSD in European ancestry individuals. These loci showed genome-wide significant associations with SCZ and nominal associations with PTSD but with opposite directions of effect. The analysis included trans-ancestry meta-analysis validation and focused particularly on the rs62062288 variant at the MAPT/CRHR1 locus on chromosome 17q21.31, which showed a risk effect for PTSD and protective effect for SCZ.
Differential GWAS analysis using PGC summary statistics, followed by trans-ancestry meta-analysis validation and GTEx expression quantitative trait locus (eQTL) analysis to examine regulatory effects on gene expression in brain tissues
Identification of genetic loci with opposing effects on SCZ and PTSD risk, with validation of brain-region-specific regulatory effects on target genes
genome-wide significance threshold P < 5 × 10^-8 for differential associations
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