🧫
Perampanel effect on dynamin1 phosphorylation in wild-type mice
active
experiment
Created: 2026-04-11T00:48:31
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-87af377b-ab48-4387-be91-a4a3097af4d2
🧫 Experiment Protocol
ValidationLewy body diseaseDNM1wild-type miceproposed
This experiment evaluated the effect of perampanel administration on dynamin1 phosphorylation levels in mouse brains. Wild-type mice were treated with perampanel orally, and brain tissue was analyzed using western blotting to measure both total dynamin1 and phosphorylated dynamin1 levels. This was designed to test whether perampanel modulates dynamin-dependent endocytosis in vivo by affecting dynamin1 phosphorylation status.
PRIMARY OUTCOME
levels of dynamin1 and phosphorylated dynamin1
EXPECTED OUTCOMES
increased phosphorylated dynamin1 levels with perampanel treatment
SUCCESS CRITERIA
significant increase in phosphorylated dynamin1
PROTOCOL
oral administration of perampanel followed by western blot analysis of brain tissue
Source: PMID 41508763 ↗
🧫 Experiment Extras
PATHWAY
endocytosis, dynamin signaling
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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