🧫
MAP6 depletion effects on neuronal development in primary cultures
active
experiment
Created: 2026-04-06T12:32:24
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-9da1becb-16e2-49b8-9ae7-b61559d0ec12
🧫 Experiment Protocol
ExploratoryMAP6primary rodent neuronal culturesproposed
This experiment investigated the effects of MAP6 protein depletion on neuronal development parameters using primary rodent neuronal cultures. MAP6 association with microtubules causes them to be stable, opposite to tau's effect. The researchers examined how MAP6 depletion affects the rate of neuronal development, growth cone turning efficiency, and the number of neuronal processes and axonal branches. The study was designed to compare MAP6's effects with those of tau depletion to understand their antagonistic relationship in regulating neuronal morphology through microtubule stability modulation.
PRIMARY OUTCOME
rate of neuronal development, growth cone turning efficiency, neuronal process number, axonal branch number
EXPECTED OUTCOMES
opposite effects to tau depletion on neuronal development parameters
SUCCESS CRITERIA
measurable changes opposite to those seen with tau depletion
PROTOCOL
MAP6 depletion in primary neuronal cultures with measurement of developmental parameters
Source: PMID 39257379 ↗
🧫 Experiment Extras
PATHWAY
microtubule dynamics
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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