🧫
Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.
active
experiment
Created: 2026-04-27T23:17:53
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-dff164a6df75
🧫 Experiment Protocol
Genetic AssociationAlzheimer's diseasecancer driver genes; clonal hematopoiesis genes (CSF1R)in_vivoextracted
Three orthogonal methods used across three independent AD cohorts; bulk RNA sequencing approach for variant detection
PRIMARY OUTCOME
Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.
LINKED HYPOTHESES
Source: pmid_38260600
🧫 Experiment Extras
PATHWAY
somatic mutation accumulation; clonal hematopoiesis
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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