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Midlife hypertension was associated with 0.15-SD faster NfL increase and 0.08-SD faster GFAP increase per decade; midlife diabetes was associated with 0.11-SD faster NfL and 0.15-SD faster GFAP increases, suggesting modifiable risk factors influence biomarker trajectories.
active
experiment
Created: 2026-04-27T23:25:10
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-f07b0b0ccb0d
🧫 Experiment Protocol
ClinicalAlzheimer's diseasehumanextracted
Midlife risk factors (hypertension, diabetes, lipids, coronary heart disease, cigarette use, physical activity) assessed in 1993-1995.
PRIMARY OUTCOME
Midlife hypertension was associated with 0.15-SD faster NfL increase and 0.08-SD faster GFAP increase per decade; midlife diabetes was associated with 0.11-SD faster NfL and 0.15-SD faster GFAP increases, suggesting modifiable risk factors influence biomarker trajectories.
LINKED HYPOTHESES
Source: pmid_39068543
🧫 Experiment Extras
PATHWAY
cardiovascular risk factors
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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