🧫

Synaptic plasticity and protein expression analysis in mPFC

experiment Created: 2026-04-10 22:36:30 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-03a934e0-f1ad-47aa-9dcd-9
🧫 Experiment Protocol Gene Expression
🧫 View Full Experiment Page →
Related Entities
PACAP, PSD95, synapsin-1, BDNF, eEF2
Metadata
experiment_typegene_expression
protocolLTP recordings in mPFC slices, protein quantification via Western blot or similar techniques
expected_outcomesZG treatment would restore impaired LTP and increase synaptic protein expression
success_criteriaSignificant improvement in LTP and increased expression of synaptic proteins
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:36:30.019047
source_pmid41525914
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:36:30.059833'}
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (82)
mentions📖BDNF Neurons80%
mentions📖BDNF Neurons80%
mentions📖BDNF Therapy for Neurodegeneration — Investment Landscape An80%
mentions📖Eukaryotic Translation Elongation Factor 2 (EEF2)80%
mentions📖pacap-receptor-modulators-neurodegeneration80%
mentions📖DLG4 Gene80%
related📖BDNF Neurons72%
related📖BDNF Neurons72%
related📖BDNF Therapy for Neurodegeneration — Investment Landscape An72%
related📖Eukaryotic Translation Elongation Factor 2 (EEF2)72%
related📖pacap-receptor-modulators-neurodegeneration72%
mentions📖SYN1 (Synapsin-1)70%
mentions📖BDNF - Neurotrophic Factor Biomarker70%
mentions📖BDNF Gene70%
mentions📖BDNF/Neurotrophin Signaling in Neurodegeneration70%
mentions📖BDNF Signaling Pathway in Neurodegeneration70%
mentions📖BDNF Signaling Pathway in Neurodegeneration70%
mentions📖bdnf-trophic-loss-huntingtons70%
mentions📖Brain-Derived Neurotrophic Factor (BDNF)70%
mentions📖BDNF Protein70%
mentions📖BDNF Therapies70%
mentions📖BDNF Therapy for Neurodegeneration70%
mentions📖PACAP Neurons70%
mentions📖PACAP/VPAC Receptor Neurons70%
related📖SYN1 (Synapsin-1)63%
related📖BDNF - Neurotrophic Factor Biomarker63%
related📖BDNF Gene63%
related📖BDNF/Neurotrophin Signaling in Neurodegeneration63%
related📖BDNF Signaling Pathway in Neurodegeneration63%
related📖BDNF Signaling Pathway in Neurodegeneration63%
related📖bdnf-trophic-loss-huntingtons63%
related📖Brain-Derived Neurotrophic Factor (BDNF)63%
related📖BDNF Protein63%
related📖BDNF Therapies63%
related📖BDNF Therapy for Neurodegeneration63%
related📖PACAP Neurons63%
related📖PACAP/VPAC Receptor Neurons63%
mentions📖Long-Term Potentiation (LTP)60%
mentions📖Long-Term Potentiation (LTP)60%
mentions📖Medial Prefrontal Cortex60%
mentions📖Protein Synthesis Pathway60%
related📖Long-Term Potentiation (LTP)54%
related📖Long-Term Potentiation (LTP)54%
related📖Medial Prefrontal Cortex54%
related📖Protein Synthesis Pathway54%
mentions📖Neuropeptide and Endocrine Signaling in CBS/PSP50%
mentions📖PAC1 (ADCYAP1R1) Receptor Neurons50%
mentions📖Advanced Neuropeptide Signaling in CBS/PSP50%
mentions📖Parabrachial Neurons50%
mentions📖VPAC2 Receptor Neurons50%
mentions📖VPAC1 Receptor Neurons50%
mentions📖Hippocampal CA3 Neurons50%
mentions📖Synaptic Dysfunction in Alzheimer's Disease50%
mentions📖Transdiagnostic Proteomic Changes in Neurodegeneration50%
mentions📖Dendritic Spines50%
mentions📖Shank Scaffold Protein Neurons50%
mentions📖Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in N50%
mentions📖Synaptic Spine Degradation Pathway in Alzheimer's Disea50%
mentions📖Synaptic Loss in Alzheimer's Disease Pathway50%
mentions📖Postsynaptic Densities50%
mentions📖Arcuate Nucleus Dopamine Neurons44%
mentions📖Bed Nucleus of the Stria Terminalis (BNST) Neurons44%
mentions📖Edinger-Westphal Nucleus Neurons44%
mentions📖Edinger-Westphal Nucleus44%
mentions📖Striatal Cholinergic Interneurons44%
mentions📖Suprachiasmatic Nucleus Neurons44%
mentions📖Vasoactive Intestinal Peptide Neurons44%
mentions📖SPAM1-SIRT6 Positive Allosteric Modulator in Neurodegenerati44%
mentions📖SPAM1: SIRT6 Positive Allosteric Modulator44%
mentions📖Dendritic Spine-Deficient Neurons44%
mentions📖iPSC-Derived Hippocampal Neurons44%
mentions📖Schizophrenia44%
mentions📖Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precur44%
mentions📖Complement Pathway Inhibition Therapy for Neurodegeneration44%
mentions📖5xFAD Mouse Model44%
mentions📖APOE Lipid Dysregulation Causal Chain in AD44%
mentions📖Convergent Pathways in Neurodegeneration44%
mentions📖LRP1-ApoE Signaling Cascade44%
mentions📖Spatial Transcriptomics of Progressive Supranuclear Palsy44%
related🧫PACAP agonist rescue experiment in sleep-deprived mice16%
related🧫mPFC PACAP knockdown validation experiment16%
related📖DLG4 Gene16%