🧫

cGAMP biomarker analysis in ALS patient spinal cord samples

experiment Created: 2026-04-06 12:28:36 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-171a9eac-18ec-44fd-a73e-d
🧫 Experiment Protocol Clinical
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Metadata
experiment_typeclinical
protocolMeasurement of cGAMP metabolite levels in post-mortem spinal cord samples from ALS patients compared to controls
expected_outcomesElevated cGAMP levels in ALS patient spinal cord samples
success_criteriaSignificantly higher cGAMP levels in ALS patients versus controls
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:28:36.707808
source_pmid33031745
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:28:36.767307'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (162)
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mentions📖ALS-FTD Overlap Neurons70%
mentions📖ALS Pipeline70%
mentions📖ALS Pipeline Companies70%
mentions📖ALS-FTD-Parkinsonism Comparison Matrix70%
mentions📖ALS-FTD Spectrum70%
mentions📖ALS Progression Rate Heterogeneity70%
mentions📖ALS Progression Rate Heterogeneity — mechanism and biomarker70%
mentions📖ALS Regional Onset and Spread: Network-Level Staging Model70%
mentions📖gaps-als70%
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mentions📖ALS Trial Failures Knowledge Gap70%
mentions📖ALS Association70%
mentions📖ALS Clinical Trials Consortium (NEALS)70%
mentions📖ALS vs FTD: Comparative Investment Analysis70%
mentions📖ALS Biomarker-to-Mechanism Mapping70%
mentions📖ALS Biomarkers and Disease Monitoring70%
mentions📖ALS Combination Therapy Matrix70%
mentions📖ALS Cure Roadmap70%
mentions📖ALS Failed Approaches Analysis70%
mentions📖ALS-FTD Overlap: Mechanistic Pathways70%
mentions📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms70%
mentions📖ALS Knowledge Gaps Ranked List70%
mentions📖ALS Disease Spectrum vs Molecular Subtypes70%
mentions📖ALS Mechanistic Pathway70%
mentions📖ALS Progression Trajectories70%
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mentions📖ALS Therapeutics70%
mentions📖ALS Treatment Overview70%
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mentions📖AMP-PD: Accelerating Medicines Partnership: Parkinson's70%
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mentions📖DNA Damage and Repair in Neurons70%
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related📖ALS-FTD Overlap Neurons63%
related📖ALS Pipeline63%
related📖ALS Pipeline Companies63%
related📖ALS-FTD-Parkinsonism Comparison Matrix63%
related📖ALS-FTD Spectrum63%
related📖ALS Progression Rate Heterogeneity63%
related📖ALS Progression Rate Heterogeneity — mechanism and biomarker63%
related📖ALS Regional Onset and Spread: Network-Level Staging Model63%
related📖gaps-als63%
related📖gaps-als-immune-signature-stratification63%
related📖gaps-als-motor-neuron-vulnerability63%
related📖gaps-als-progression-rate-heterogeneity63%
related📖gaps-als-regional-onset-spread63%
related📖ALS Trial Failures Knowledge Gap63%
related📖ALS Association63%
related📖ALS Clinical Trials Consortium (NEALS)63%
related📖ALS vs FTD: Comparative Investment Analysis63%
related📖ALS Biomarker-to-Mechanism Mapping63%
related📖ALS Biomarkers and Disease Monitoring63%
related📖ALS Combination Therapy Matrix63%
related📖ALS Cure Roadmap63%
related📖ALS Failed Approaches Analysis63%
related📖ALS-FTD Overlap: Mechanistic Pathways63%
related📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms63%
related📖ALS Knowledge Gaps Ranked List63%
related📖ALS Disease Spectrum vs Molecular Subtypes63%
related📖ALS Mechanistic Pathway63%
related📖ALS Progression Trajectories63%
related📖ALS RNA Metabolism and Proteostasis Failure63%
related📖ALS Therapeutic Scorecard63%
related📖ALS Trial Failure Analysis63%
related📖ALS Communication Brain-Computer Interfaces63%
related📖ALS Cure Roadmap63%
related📖ALS Therapeutic Landscape — Programs by Phase and Modality63%
related📖ALS Therapeutics63%
related📖ALS Treatment Overview63%
related📖ALS Treatment Strategies63%
related📖AMP-PD: Accelerating Medicines Partnership: Parkinson's63%
related📖DNA Methylation Biomarkers in Neurodegeneration63%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration63%
related📖DNA Damage and Repair in Neurons63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Methylation63%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#63%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 63%
related📖DNA Damage Repair Therapy - Biomarker Guided63%
related📖DNA Damage Repair Investment Landscape63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖dna-damage-repair63%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas63%
related📖DNA Damage Response Impairment Pathway63%
related📖DNA Damage Response in 4R-Tauopathies63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Damage Response and Repair in Neurodegeneration63%
related📖DNA Damage Response in Neurons63%
related📖DNA Damage Response in Parkinson's Disease63%
related📖DNA Damage Response in Neurodegeneration63%
related📖DNA Methylation in Neurodegeneration63%
related📖DNA Repair Mechanisms in Neurodegeneration63%
related📖DNA Sensing Pathways in Neurodegeneration63%
related📖DNA Damage and Repair Dysfunction in PSP63%
related📖DNA Ligase III Protein63%
related📖DNA Ligase IV Protein63%
related📖DNA-PKcs (PRKDC) Protein63%
related📖DNA Damage Repair Therapy for Neurodegeneration63%
related📖DNA Repair Therapy for Neurodegeneration63%
related📖STING Gene63%
related📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease63%
related📖proteins-sting-protein63%
related📖STING Protein63%
related📖STING Inhibitor Therapy in Neurodegeneration63%
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mentions📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
mentions📖Bulbar Amyotrophic Lateral Sclerosis60%
mentions📖FUS Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖SOD1 Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖Spinal Amyotrophic Lateral Sclerosis60%
mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖Mitochondria60%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
related📖Amyotrophic Lateral Sclerosis (ALS)54%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants54%
related📖Bulbar Amyotrophic Lateral Sclerosis54%
related📖FUS Mutations in Amyotrophic Lateral Sclerosis54%
related📖SOD1 Mutations in Amyotrophic Lateral Sclerosis54%
related📖Spinal Amyotrophic Lateral Sclerosis54%
related📖TARDBP Mutations in Amyotrophic Lateral Sclerosis54%
related📖Mitochondria54%