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DNA Ligase IV Protein

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slug	proteins-lig4-protein
entity_type	protein
kg_node_id	LIG4PROTEIN

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Linked Artifacts (133)

mentions🔬Epigenetic reprogramming in aging neurons75%

mentions🔬How do dilncRNAs specifically drive molecular crowding and p75%

mentions🔬What determines the specificity of DDR protein recruitment t75%

mentions🧫Factor depletion effects on DDR focus formation in vivo70%

mentions🧫cGAMP biomarker analysis in ALS patient spinal cord samples70%

mentions🧫TFAM and mtDNA analysis in AKI patients70%

mentions🧫Longitudinal TLR2 reporter gene study in α-synuclein mice70%

mentions🧫DSB-induced promoter assembly and RNA polymerase II recruitm70%

mentions🧫In vitro DDR reconstitution on nucleosomes70%

mentions🧫dilncRNA-mediated molecular crowding and phase separation70%

mentions🧫GWAS of plasma pTau217 in East Asian cohort70%

mentions🧫Single-cell RNA-seq analysis of mouse testes with gonadal de70%

mentions🧫cGAMP biomarker analysis in ALS patient spinal cord samples70%

mentions🧫TDP-43 mitochondrial invasion and DNA release via mPTP70%

mentions🧫DSB-induced promoter assembly and RNA polymerase II recruitm70%

mentions🧫mtROS effects on TFAM and mtDNA in HK2 cells70%

mentions🧫BDEV injection and recipient microglial transcriptome analys70%

mentions🧫TDP-43 mitochondrial invasion and mtDNA release in iPSC moto70%

mentions🧫IRF1 transcriptional regulation of Nlrc5 and Ciita promoters70%

mentions🧫Epigenetic clocks association with brain aging patterns in o70%

mentions🧫cGAS/STING pathway activation by TDP-43-released mtDNA70%

mentions🧫Proposed experiment from debate on Epigenetic clocks and bio70%

mentions🧫s:** - Temporal analysis showing mitochondrial defects prece70%

mentions🧫Proposed experiment from debate on Mitochondrial transfer be70%

mentions🧫s:** - Single-cell RNA-seq to measure editing efficiency acr70%

mentions🧫Proposed experiment from debate on Senolytics targeting p16/70%

mentions🧫DDR factor depletion and focus formation analysis70%

mentions🧫E2F regulation of endocycles in trophoblast giant cells70%

mentions🧫Biomechanical Impact Profiles and Chronic Traumatic Encephal70%

mentions🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk70%

mentions🧫Antiviral Therapy Trial for Parkinson's Disease70%

mentions🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT70%

mentions🧫cGAS-STING Pathway Validation Study in Parkinson's Dise70%

mentions🧫Genetic Risk Modifiers in DLB Phenotype70%

mentions🧫DNA Damage Repair Deficiency Validation Study in Parkinson&#70%

mentions🧫Mechanism: Selective Vulnerability of Dopaminergic Neurons i70%

mentions🧫Epigenetic Clocks in Neurodegeneration — Causal Drivers or P70%

mentions🧫Epigenetic Dysregulation in Huntington's Disease — Ther70%

mentions🧫Epigenetic Dysregulation Validation in Parkinson's Dise70%

mentions🧫Epigenetic Regulation Dysfunction in Alzheimer's and Pa70%

mentions🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio70%

mentions🧫Cytochrome Therapeutics70%

mentions🧫Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in 70%

mentions🧫Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag70%

mentions🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr70%

mentions🧫Mixed Pathology Effects on Parkinson's Disease Progress70%

mentions🧫Experiment: Multi-Ethnic PD GWAS70%

mentions🧫NLRP3 Inflammasome Validation Study in Parkinson's Dise70%

mentions🧫Regulated Necrosis Validation Study in Parkinson's Dise70%

mentions🧫Selective Neuronal Vulnerability to Aging — Mapping Why Spec70%

mentions🧫Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer&#70%

mentions🧫Sex Differences in Alzheimer's Disease — mechanisms and70%

mentions🧫Traumatic Brain Injury and Alzheimer's Disease Relation70%

mentions🧫TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an70%

mentions🧫Viral Infections and Alzheimer's Disease — causal mecha70%

mentions🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des70%

related🔬Epigenetic reprogramming in aging neurons67%

related🔬How do dilncRNAs specifically drive molecular crowding and p67%

related🔬What determines the specificity of DDR protein recruitment t67%

related🧫Factor depletion effects on DDR focus formation in vivo63%

related🧫cGAMP biomarker analysis in ALS patient spinal cord samples63%

related🧫TFAM and mtDNA analysis in AKI patients63%

related🧫Longitudinal TLR2 reporter gene study in α-synuclein mice63%

related🧫DSB-induced promoter assembly and RNA polymerase II recruitm63%

related🧫In vitro DDR reconstitution on nucleosomes63%

related🧫dilncRNA-mediated molecular crowding and phase separation63%

related🧫GWAS of plasma pTau217 in East Asian cohort63%

related🧫Single-cell RNA-seq analysis of mouse testes with gonadal de63%

related🧫cGAMP biomarker analysis in ALS patient spinal cord samples63%

related🧫TDP-43 mitochondrial invasion and DNA release via mPTP63%

related🧫DSB-induced promoter assembly and RNA polymerase II recruitm63%

related🧫mtROS effects on TFAM and mtDNA in HK2 cells63%

related🧫BDEV injection and recipient microglial transcriptome analys63%

related🧫TDP-43 mitochondrial invasion and mtDNA release in iPSC moto63%

related🧫IRF1 transcriptional regulation of Nlrc5 and Ciita promoters63%

related🧫Epigenetic clocks association with brain aging patterns in o63%

related🧫cGAS/STING pathway activation by TDP-43-released mtDNA63%

related🧫Proposed experiment from debate on Epigenetic clocks and bio63%

related🧫s:** - Temporal analysis showing mitochondrial defects prece63%

related🧫Proposed experiment from debate on Mitochondrial transfer be63%

related🧫s:** - Single-cell RNA-seq to measure editing efficiency acr63%

related🧫Proposed experiment from debate on Senolytics targeting p16/63%

related🧫DDR factor depletion and focus formation analysis63%

related🧫E2F regulation of endocycles in trophoblast giant cells63%

related🧫Biomechanical Impact Profiles and Chronic Traumatic Encephal63%

related🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk63%

related🧫Antiviral Therapy Trial for Parkinson's Disease63%

related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT63%

related🧫cGAS-STING Pathway Validation Study in Parkinson's Dise63%

related🧫Genetic Risk Modifiers in DLB Phenotype63%

related🧫DNA Damage Repair Deficiency Validation Study in Parkinson&#63%

related🧫Mechanism: Selective Vulnerability of Dopaminergic Neurons i63%

related🧫Epigenetic Clocks in Neurodegeneration — Causal Drivers or P63%

related🧫Epigenetic Dysregulation in Huntington's Disease — Ther63%

related🧫Epigenetic Dysregulation Validation in Parkinson's Dise63%

related🧫Epigenetic Regulation Dysfunction in Alzheimer's and Pa63%

related🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio63%

related🧫Cytochrome Therapeutics63%

related🧫Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in 63%

related🧫Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag63%

related🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr63%

related🧫Mixed Pathology Effects on Parkinson's Disease Progress63%

related🧫Experiment: Multi-Ethnic PD GWAS63%

related🧫NLRP3 Inflammasome Validation Study in Parkinson's Dise63%

related🧫Regulated Necrosis Validation Study in Parkinson's Dise63%

related🧫Selective Neuronal Vulnerability to Aging — Mapping Why Spec63%

related🧫Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer&#63%

related🧫Sex Differences in Alzheimer's Disease — mechanisms and63%

related🧫Traumatic Brain Injury and Alzheimer's Disease Relation63%

related🧫TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an63%

related🧫Viral Infections and Alzheimer's Disease — causal mecha63%

related🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des63%

see_also📖Neurodegeneration60%

mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%

mentions🧪Serine/Arginine-Rich Protein Kinase Modulation50%

mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying protein aggregation cross50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬RNA binding protein dysregulation across ALS FTD and AD50%

mentions🔬What are the mechanisms underlying protein aggregation cross40%

mentions🔬What are the mechanisms underlying rna binding protein dysre40%

mentions🔬RNA binding protein dysregulation across ALS FTD and AD40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%

related🧪Heat Shock Protein 70 Disaggregase Amplification40%

related🧪Serine/Arginine-Rich Protein Kinase Modulation40%