Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susceptibility

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active

experiment Created: 2026-04-10T23:13:02 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-21448d10-6b1e-46da-bf4f-9

🧫 Experiment Protocol Genetic Associationproposed

N = 12,759 total (6,455 AD cases, 6,304 controls)

Related Entities

LRP1

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T23:13:02.930858'}
p_value	0.172
protocol	Systematic literature review and meta-analysis of case-control studies. Studies were identified and data extracted for genotype frequencies in AD cases versus controls. Statistical analysis included c
effect_size	OR = 0.920 (95% CI = 0.817-1.037) for overall analysis
sample_size	12,759 total (6,455 AD cases, 6,304 controls)
source_pmid	28814781
extracted_at	2026-04-10T16:13:02.928208
_schema_version	1
experiment_type	genetic_association
success_criteria	Statistically significant associations (P < 0.05) between polymorphism and AD risk in overall or subgroup analyses
expected_outcomes	Clarification of the association between LRP1 C766T polymorphism and AD risk across different populations and AD subtypes
statistical_methods	Meta-analysis with odds ratio calculations, 95% confidence intervals, subgroup analysis by ethnicity and AD onset type

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

24

Outgoing

24

0 supporting 0 contradicting 0 neutral

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💬 Discussion