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Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susceptibility
experiment
Created: 2026-04-10 23:13:02
By: experiment_extractor
Quality:
95%
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ID: experiment-exp-21448d10-6b1e-46da-bf4f-9
🧫 Experiment Protocol
Genetic Association
Related Entities
Metadata
| experiment_type | genetic_association |
| protocol | Systematic literature review and meta-analysis of case-control studies. Studies were identified and data extracted for genotype frequencies in AD cases versus controls. Statistical analysis included c |
| expected_outcomes | Clarification of the association between LRP1 C766T polymorphism and AD risk across different populations and AD subtypes |
| success_criteria | Statistically significant associations (P < 0.05) between polymorphism and AD risk in overall or subgroup analyses |
| sample_size | 12,759 total (6,455 AD cases, 6,304 controls) |
| statistical_methods | Meta-analysis with odds ratio calculations, 95% confidence intervals, subgroup analysis by ethnicity and AD onset type |
| p_value | 0.172 |
| effect_size | OR = 0.920 (95% CI = 0.817-1.037) for overall analysis |
| extracted_at | 2026-04-10T16:13:02.928208 |
| source_pmid | 28814781 |
| _origin | {'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T23:13:02.930858'} |
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