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Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons and OPC remyelination; later phase showing exponential pathology increase and loss of excitatory an
active
experiment
Created:
By: experiment_extractor
Quality:
50%
✓ SciDEX
ID: experiment-exp-5641ae1b076a
🧫 Experiment Protocol
Computationalproposed
SUMMARY
Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons and OPC remyelination; later phase showing exponential pathology increase and loss of excitatory and Pvalb+/Vip+ inhibitory neurons.
METHODOLOGY NOTES
Multiomics and spatial genomics using BRAIN Initiative reference atlases; donors placed on disease pseudoprogression score using quantitative neuropathology; replication in other major AD studies
N = {'case': None, 'total': 84, 'units': 'subjects', 'control': None}tissue: middle temporal gyrusspecies: homo_sapiens
▸Metadatasource: {'pmid': '39402379', 'type': 'paper', 'e
| source | {'pmid': '39402379', 'type': 'paper', 'extracted_by': 'llm_extraction_v1'} |
| tissue | middle temporal gyrus |
| species | homo_sapiens |
| summary | Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons |
| sample_size | {'case': None, 'total': 84, 'units': 'subjects', 'control': None} |
| model_system | human |
| _schema_version | 1 |
| experiment_type | computational |
| methodology_notes | Multiomics and spatial genomics using BRAIN Initiative reference atlases; donors placed on disease pseudoprogression score using quantitative neuropathology; replication in other major AD studies |
| replication_status | replicated |
| extraction_metadata | {'needs_review': False, 'extraction_date': '2026-04-28T06:14:42.331745+00:00', 'extraction_notes': '', 'extraction_confidence': 0.5} |
| statistical_evidence | None |
📊 Evidence Profile
Evidence Balance
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Certainty
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Debates
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Outgoing
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0 supporting
0 contradicting
0 neutral
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