🧫
Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% of microglia carrying pathogenic sSNVs.
active
experiment
Created:
By: experiment_extractor
Quality:
50%
✓ SciDEX
ID: experiment-exp-6ca747a7175f
🧫 Experiment Protocol
Genetic Associationproposed
SUMMARY
Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% of microglia carrying pathogenic sSNVs.
METHODOLOGY NOTES
Molecular-barcoded deep sequencing (>1000X coverage); analysis of sSNVs and sIndels in cancer driver genes
N = {'case': None, 'total': 311, 'units': 'samples', 'control': None}tissue: prefrontal cortexspecies: homo_sapiens
Related Entities
▸Metadatasource: {'pmid': '38260600', 'type': 'paper', 'e
| source | {'pmid': '38260600', 'type': 'paper', 'extracted_by': 'llm_extraction_v1'} |
| tissue | prefrontal cortex |
| species | homo_sapiens |
| summary | Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% o |
| sample_size | {'case': None, 'total': 311, 'units': 'samples', 'control': None} |
| model_system | in_vivo |
| _schema_version | 1 |
| experiment_type | genetic_association |
| methodology_notes | Molecular-barcoded deep sequencing (>1000X coverage); analysis of sSNVs and sIndels in cancer driver genes |
| replication_status | replicated |
| extraction_metadata | {'needs_review': False, 'extraction_date': '2026-04-28T06:18:28.445726+00:00', 'extraction_notes': '', 'extraction_confidence': 0.5} |
| statistical_evidence | {'p_value': None, 'test_type': None, 'effect_size': {'value': None, 'measure': 'enrichment', 'direction': 'increased'}} |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.