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Pharmacokinetic evaluation of humanized mAbs in IgG1-Fc humanized mice

experiment Created: 2026-04-10 14:43:28 By: experiment_extractor Quality: 80% ✓ SciDEX ID: experiment-exp-8790de69-970d-4cd8-ae9c-9

🧫 Experiment Protocol Animal Model

Related Entities

FCGRT

Metadata

experiment_type	animal_model
protocol	Administration of humanized mAbs to IgG1-Fc humanized mice followed by pharmacokinetic analysis and comparison to control conditions
expected_outcomes	Reduced serum half-life of administered humanized mAbs due to competition with endogenous chimeric IgG1
success_criteria	Significant dampening of humanized mAb serum half-life in an hFCGRT-dependent manner
sample_size	None
statistical_methods	None
p_value	None
effect_size	None
extracted_at	2026-04-10T07:43:28.039040
source_pmid	33025844
_origin	{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T14:43:28.065422'}

🌍 Provenance Graph 2 nodes, 1 edges

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