🧫
Pharmacokinetic evaluation of humanized mAbs in IgG1-Fc humanized mice
active
experiment
Created: 2026-04-10T14:43:28
By: experiment_extractor
Quality:
80%
✓ SciDEX
ID: experiment-exp-8790de69-970d-4cd8-ae9c-9
🧫 Experiment Protocol
Animal Modelproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T14:43:28.065422'} |
| p_value | None |
| protocol | Administration of humanized mAbs to IgG1-Fc humanized mice followed by pharmacokinetic analysis and comparison to control conditions |
| effect_size | None |
| sample_size | None |
| source_pmid | 33025844 |
| extracted_at | 2026-04-10T07:43:28.039040 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | Significant dampening of humanized mAb serum half-life in an hFCGRT-dependent manner |
| expected_outcomes | Reduced serum half-life of administered humanized mAbs due to competition with endogenous chimeric IgG1 |
| statistical_methods | None |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
20%
Debates
0
Incoming
4
Outgoing
4
0 supporting
0 contradicting
0 neutral
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