🧫
PPP3/calcineurin-dependent TFEB dephosphorylation mechanism
active
experiment
Created: 2026-04-06T12:28:58
By: experiment_extractor
Quality:
80%
✓ SciDEX
ID: experiment-exp-ad6850c9-f4ec-48ac-9df6-a
🧫 Experiment Protocol
Protein Interactionproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:28:58.521361'} |
| p_value | None |
| protocol | Calcium imaging, immunofluorescence microscopy, western blotting for phospho-TFEB, subcellular fractionation, phosphatase activity assays |
| effect_size | None |
| sample_size | None |
| source_pmid | 30335591 |
| extracted_at | 2026-04-06T05:28:58.489681 |
| _schema_version | 1 |
| experiment_type | protein_interaction |
| success_criteria | Demonstration of calcium-dependent TFEB dephosphorylation and nuclear translocation that can be blocked by calcineurin inhibitors |
| expected_outcomes | Lysosomal calcium release would activate calcineurin, leading to TFEB dephosphorylation and nuclear translocation |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
75%
Debates
0
Incoming
15
Outgoing
18
0 supporting
0 contradicting
0 neutral
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