gene

PPP3CB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP3CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

191Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

Summary

PPP3CB is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 119 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PPP3CB
Full Name	PPP3CB
Chromosome	2p22.1
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	61 kDa
Amino Acids	524 aa
Pathways	Autophagy, Chaperone, Mtor, Tdp-43, autophagy pathway
UniProt ID	P16234
NCBI Gene ID	5519
Ensembl ID	ENSG00000107738
GeneCards	PPP3CB
Human Protein Atlas	PPP3CB
Associated Diseases	ALS, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma
Known Drugs/Compounds	rapamycin
Interactions	ATG10, CALCINEURIN, ATG12, TFEB, MTOR, LGALS3
KG Connections	191 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPP3CB — AlphaFold P16234 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PPP3CB["PPP3CB"]
    PPP3CB -->|"binds"| TFEB["TFEB"]
    PPP3CB -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PPP3CB -->|"interacts"| Als["Als"]
    PPP3CB -->|"activates"| Ms["Ms"]
    PPP3CB -->|"activates"| ATG10["ATG10"]
    PPP3CB -->|"activates"| GENES["GENES"]
    PPP3CB -->|"activates"| CALCINEURIN["CALCINEURIN"]
    PPP3CB -->|"activates"| ATG12["ATG12"]
    SMURF1["SMURF1"] -->|"ubiquitinates"| PPP3CB
    LGALS3["LGALS3"] -->|"binds"| PPP3CB
    CALCINEURIN -->|"activates"| PPP3CB
    ATG12 -->|"activates"| PPP3CB
    CTSB["CTSB"] -->|"expressed in"| PPP3CB
    MTOR["MTOR"] -->|"activates"| PPP3CB
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| PPP3CB
    TREHALOSE["TREHALOSE"] -->|"activates"| PPP3CB

Outgoing (117)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	activates	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
SOD1	activates	entity	0.60
SQSTM1	activates	entity	0.60
STIP1	activates	entity	0.60
STUB1	activates	entity	0.60
TARDBP	activates	entity	0.60
TPP1	activates	entity	0.60
TREH	activates	entity	0.60
HSPB8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
ATG10	activates	gene	0.60
LAMP1	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
P62	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BECN1	associated_with	gene	0.60
ATG12	activates	gene	0.60
GLA	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
TREH	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
TFEB	activates	gene	0.60
MTOR	activates	gene	0.60
LGALS3	interacts_with	gene	0.60

Incoming (74)

Source	Relation	Type	Str
LGALS3	binds	protein	0.70
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
CTSB	activates	entity	0.60
GAPDH	activates	entity	0.60
GLA	activates	entity	0.60
HSPA8	activates	entity	0.60
HSPB8	activates	entity	0.60
LAMP1	activates	entity	0.60
LAMP2A	activates	entity	0.60
LGALS3	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MCOLN1	activates	entity	0.60
P62	activates	entity	0.60
PPARGC1A	activates	entity	0.60
ALS	activates	entity	0.60
STIP1	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TREH	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
CTSB	expressed_in	gene	0.60
MTOR	activates	gene	0.60
LGALS3	interacts_with	gene	0.60
MTOR	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
ATG10	activates	gene	0.60
TFEB	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
AR	activates	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
TREHALOSE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PPP3/calcineurin-dependent TFEB dephosphorylation mechanism	exploratory	motoneuron degeneration	0.800	0.00	neuronal cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PPP3CB

Understanding Entity Pages

Summary

Wiki Pages (13)

PPP3CB Gene

PP2B Protein (Calcineurin)

PPP3CB Protein

PPP3CC Gene (Calcineurin Gamma)

TFE3 Gene

PPP3CA (Calcineurin Aα) — Protein Phosphatase 3 Catalytic Subunit Alpha

CALM5

RCAN1 Protein

Calcineurin A Protein

Calmodulin-2 Protein

ATG12 Protein

Proteins