🧫
IRF1 transcriptional regulation of Nlrc5 and Ciita promoters
active
experiment
Created: 2026-04-10T14:35:17
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-b864fb80-4fa9-433d-b46c-1
🧫 Experiment Protocol
Gene Expressionproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T14:35:17.420571'} |
| p_value | None |
| protocol | Dual-luciferase reporter assays to measure promoter activity and ChIP-qPCR to assess IRF1 DNA binding to target promoters |
| effect_size | None |
| sample_size | None |
| source_pmid | 39402629 |
| extracted_at | 2026-04-10T07:35:17.187171 |
| _schema_version | 1 |
| experiment_type | gene_expression |
| success_criteria | Reduced IRF1 binding and transcriptional activity in presence of NPM1 |
| expected_outcomes | NPM1 would suppress IRF1-mediated transcriptional activation of MHC genes |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
44
Outgoing
44
0 supporting
0 contradicting
0 neutral
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