APOE4 association with TDP-43 pathology in AD

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APOE4 association with TDP-43 pathology in AD

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experiment Created: 2026-04-06T12:29:12 By: experiment_extractor Quality: 75% ✓ SciDEX ID: experiment-exp-e211ffa3-de74-4b6e-bfc6-c

🧫 Experiment Protocol Genetic Associationproposed

Related Entities

APOE

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:29:12.375856'}
p_value	None
protocol	APOE genotyping and neuropathological assessment for TDP-43
effect_size	None
sample_size	None
source_pmid	34930382
extracted_at	2026-04-06T05:29:12.335557
_schema_version	1
experiment_type	genetic_association
success_criteria	statistically significant association between APOE4 and TDP-43 pathology
expected_outcomes	higher TDP-43 pathology frequency in APOE4 carriers
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

Outgoing

0 supporting 0 contradicting 0 neutral

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🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

experiment-exp-e211ffa3-de74-4→paper-34930382

This artifact has no version history yet.

Linked Artifacts (119)

derives_from📄TDP-43 Pathology in Alzheimer's Disease.100%

mentions📖APOE contributes to Alzheimer's disease by regulating b90%

mentions📖APOE contributes to Alzheimer's disease by regulating b80%

mentions📖APOE Genotyping for Neurodegenerative Disease Risk Assessmen80%

mentions📖apoe-genotype-guided-prevention80%

mentions📖APOE Lipid Dysregulation Causal Chain in AD80%

mentions📖APOE contributes to Alzheimer's disease by regulating b80%

mentions📖APOE - Apolipoprotein E80%

mentions📖APOE Lipid Metabolism Pathway in Alzheimer's Disease80%

mentions📖APOE — Apolipoprotein E80%

mentions📖APOE-Expressing Astrocytes80%

related📖APOE — Apolipoprotein E72%

related📖APOE - Apolipoprotein E72%

related📖APOE-Expressing Astrocytes72%

related📖apoe-genotype-guided-prevention72%

mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%

mentions📖TDP-43 Proteinopathy in ALS70%

mentions📖TDP-43 Pathology in Corticobasal Syndrome70%

mentions📖TDP-43 Aggregate Neurons70%

mentions📖TDP-43 Splicing Modulation Therapy70%

mentions📖TDP-43 RNA Granule Pathway70%

mentions📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia70%

mentions📖APOE4 and Alzheimer's Disease Risk70%

mentions📖TDP-43 Pathology Reversibility in ALS70%

mentions📖TDP-43 Proteinopathy Investment Landscape70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖APOE4 (Apolipoprotein E4)70%

mentions📖APOE4 Lipid Homeostasis Modulator for Pre-Symptomatic Alzhei70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 Proteinopathy70%

mentions📖TDP-43 PET Ligand Development for Frontotemporal Dementia70%

mentions📖APOE4 Lipid Metabolism Optimization70%

mentions📖APOE4 Homozygous Astrocytes70%

mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖TDP-43 PET Ligand Development for FTD and ALS70%

mentions📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%

mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%

mentions📖tdp-43-fus-rna-proteinopathy-comparison70%

mentions📖TDP-43 Pathology in Corticobasal Syndrome70%

related📖TDP-43 Protein63%

related📖APOE4 Homozygous Astrocytes63%

related📖TDP-43 Protein63%

related📖TDP-43 Proteinopathy Neurons63%

related📖TDP-43 Aggregate Neurons63%

related📖APOE4 (Apolipoprotein E4)63%

related📖TDP-43 Proteinopathy63%

related📖TDP-43 RNA Granule Pathway63%

related📖TDP-43 Proteinopathy Neurons63%

related📖TDP-43 Proteinopathy in ALS63%

mentions📖Alzheimer's Disease Genetic Variants60%

mentions📖PSEN2 Mutations in Alzheimer's Disease60%

related📖Alzheimer's Disease60%

mentions📖Early-Onset Alzheimer's Disease (EOAD)60%

mentions📖Preclinical Alzheimer's Disease60%

mentions📖TREM2 Variants in Alzheimer's Disease60%

mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%

mentions📖Neurodegeneration60%

mentions📖APP Mutations in Alzheimer's Disease60%

mentions📖PSEN1 Mutations in Alzheimer's Disease60%

mentions📖Prodromal Alzheimer's Disease60%

mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%

mentions📖Investment Landscape: Alzheimer's Disease60%

mentions📖Alzheimer's Disease60%

mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%

mentions📖Mechanisms60%

mentions📖Agitation in Alzheimer's Disease60%

related📖Neurodegeneration54%

related📖Alzheimer's Disease54%

related📖Preclinical Alzheimer's Disease54%

related📖Agitation in Alzheimer's Disease54%

related📖Mechanisms54%

related📖Prodromal Alzheimer's Disease54%

Reference URLs

Canonical (singular)/artifact/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dccanonical

Canonical (plural, REST)/artifacts/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dcalias

Type prefix (singular)/experiment/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dcalias

Type prefix (plural)/experiments/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dcalias

API (JSON)/api/artifacts/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dcapi

Citation — BibTeX/artifacts/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc/cite?fmt=bibtexexport

Citation — RIS/artifacts/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc/cite?fmt=risexport

Citation — CSL-JSON/artifacts/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc/cite?fmt=cslexport

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[APOE4 association with TDP-43 pathology in AD](http://scidex.ai/artifact/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc)

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http://scidex.ai/artifact/experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc

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