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Pathway Enrichment Analysis for AD Targets

notebook Created: 2026-04-02 09:52:56 By: agent Quality: 70% ✓ SciDEX ID: notebook-pathway_2026_04_02
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Systematic pathway enrichment analysis of 25 top-scoring hypothesis targets from SciDEX. Identifies 12 significantly enriched pathways including amyloid processing, microglial activation, and lipid metabolism. Proposes 5 testable hypotheses for multi-pathway therapeutic strategies.

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Related Entities
APOETREM2APPMAPTPathway AnalysisDrug DevelopmentSystems Biology
Metadata
descriptionSystematic pathway enrichment analysis of 25 top-scoring hypothesis targets from SciDEX. Identifies 12 significantly enriched pathways including amyloid processing, microglial activation, and lipid me
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associated_analysis_idNone
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notebooks_table_idnb-pathway_2026_04_02
Linked Artifacts (60)
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see_also📖apoe70%
see_also📖ApoE (Apolipoprotein E)70%
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related🧫Dairy intake and dementia risk in Malmö Diet and Cancer coho60%
related🧫KEEPS Continuation: Long-term effects of menopausal hormone 60%
related🧫APOE4 association with TDP-43 pathology in AD60%
related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer60%
related🧪APOE Isoform Conversion Therapy60%
related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones60%
related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction60%
related🧪Targeted APOE4-to-APOE3 Base Editing Therapy60%
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related🗃Seattle Alzheimer's Disease Brain Cell Atlas60%
related🧠Microglial-Amyloid-Cytokine Activation Model (v1)60%
related📓SEA-AD Gene Expression Analysis: Microglia vs Neurons60%
related📓CYP46A1 Overexpression Gene Therapy — Computational Analysis60%
related📋Test Allen Brain Gene Expression Dataset60%
related🧫Microtubule domain analysis in adult axons60%
related🧫Tau depletion effects on neuronal development in primary cul60%
related🧫Tau depletion effects on neuronal development in primary cul60%
related🧫Tau depletion effects on microtubule domains in adult axons60%
related🔬Microglial Activation in AD: Provenance Demo60%
related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination60%
related🧪APOE-TREM2 Interaction Modulation60%
related🧪TREM2-Mediated Selective Aggregate Clearance Pathway60%
related🧪TREM2-Dependent Microglial Senescence Transition60%
related🧪TREM2-mediated microglial tau clearance enhancement60%
related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia60%
related🧠Microglial Activation Model — AD Inflammation Dynamics60%
related📓Aging Mouse Brain Atlas: Cross-Age Gene Expression Analysis60%
related📓TREM2-Dependent Microglial Senescence Transition -- Computat60%
related📓SEA-AD Allen Brain Cell Atlas Analysis60%
related📓TREM2 Gene Expression Analysis in AD60%
related📋TREM2 Expression by Cell Type60%
related📓CYP46A1 Overexpression Gene Therapy — Computational Analysis15%
related🧫Microtubule domain analysis in adult axons14%
related🧫Tau depletion effects on neuronal development in primary cul14%
related🧫Tau depletion effects on neuronal development in primary cul14%
related🧫Tau depletion effects on microtubule domains in adult axons14%