🧫

FK866 treatment in DSS-induced colitis mouse model

experiment Created: 2026-04-10 14:44:04 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-ecdfc305-fcd8-4767-b8cd-a
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NAMPT
Metadata
experiment_typeanimal_model
protocolDSS administration to induce colitis followed by FK866 treatment with assessment of mucosal NAD levels, enzyme activities, inflammatory cell infiltration, and cytokine production
expected_outcomesFK866 would reduce inflammation by depleting NAD and inhibiting inflammatory pathways
success_criteriaReduced colitis severity, decreased inflammatory markers, and altered immune cell populations
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T07:44:04.645402
source_pmid28877980
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T14:44:04.648064'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (56)
derives_from📄NAD metabolism fuels human and mouse intestinal inflammation100%
related🧫FK866 efficacy in IBD patient-derived lamina propria cells100%
related🧫FK866 in azoxymethane/DSS colitis-associated cancer model100%
related🧫NAD depletion effects on monocyte/macrophage differentiation100%
related🧫FK866 mechanism validation in Rag1-/- mice100%
mentions📖NAMPT Gene80%
mentions📖NAMPT Protein80%
related📖NAMPT Gene72%
related📖NAMPT Protein72%
mentions📖CD38 Molecule (CD38)70%
mentions📖CD38 Inhibition + NAD+ Precursor Synergy for Neuroprotection70%
mentions📖CD38 Inhibitor Therapy for Neurodegeneration70%
mentions📖nad-augmentation-therapy-early-ad70%
mentions📖NAD+ Bioenergetics Investment Synthesis70%
mentions📖NAD+ Metabolism in Neurodegeneration70%
mentions📖NAD+ Metabolism Pathway in Neurodegeneration70%
mentions📖NAD Signaling in Neurodegeneration70%
mentions📖NAD Kinase Protein70%
mentions📖NAD+ Boosters for Neurodegeneration70%
mentions📖NAD+ Boosters for Neurodegeneration70%
mentions📖NAD+ Precursor Therapy for Neurodegenerative Diseases70%
mentions📖NAD+ Precursors for Neurodegeneration70%
mentions📖NAD+ Precursors (NMN/NR) for Parkinson's Disease70%
mentions📖PARP1 Gene70%
mentions📖PARP1 Inhibition for Parthanatos Prevention in Neurodegenera70%
mentions📖PARP1 (Poly(ADP-Ribose) Polymerase 1)70%
mentions📖PARP1 Protein70%
related📖CD38 Molecule (CD38)63%
related📖CD38 Inhibition + NAD+ Precursor Synergy for Neuroprotection63%
related📖CD38 Inhibitor Therapy for Neurodegeneration63%
related📖nad-augmentation-therapy-early-ad63%
related📖NAD+ Bioenergetics Investment Synthesis63%
related📖NAD+ Metabolism in Neurodegeneration63%
related📖NAD+ Metabolism Pathway in Neurodegeneration63%
related📖NAD Signaling in Neurodegeneration63%
related📖NAD Kinase Protein63%
related📖NAD+ Boosters for Neurodegeneration63%
related📖NAD+ Boosters for Neurodegeneration63%
related📖NAD+ Precursor Therapy for Neurodegenerative Diseases63%
related📖NAD+ Precursors for Neurodegeneration63%
related📖NAD+ Precursors (NMN/NR) for Parkinson's Disease63%
related📖PARP1 Gene63%
related📖PARP1 Inhibition for Parthanatos Prevention in Neurodegenera63%
related📖PARP1 (Poly(ADP-Ribose) Polymerase 1)63%
related📖PARP1 Protein63%
related📓Nutrient-Sensing Epigenetic Circuit Reactivation — Computati60%
mentions📖Ventral Tegmental Area50%
mentions📖Circadian Dysregulation in Parkinson's Disease50%
mentions📖Wallerian Degeneration50%
mentions📖Section 103: Sirtuin Pathway and NAD+-Dependent Deacetylases50%
mentions📖Nicotinamide Riboside50%
mentions📖Sirtuin Pathway Dysfunction Hypothesis in Parkinson's D50%
mentions📖Ventral Tegmental Area (VTA) Dopaminergic Neurons44%
mentions📖Ventral Tegmental Area (Expanded)44%
mentions📖Sirtuin Modulators for Parkinson's Disease44%
related📓Nutrient-Sensing Epigenetic Circuit Reactivation — Computati12%