gene

NAMPT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAMPT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

608Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

NAMPT is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 221 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NAMPT
Full Name	Nicotinamide Phosphoribosyltransferase
Aliases	Visfatin, PBEF, PBEF1
Chromosome	7q22.3
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule competitive inhibitors of NAD+ biosynthesis enzyme
Mechanism of Action	Small molecule competitive inhibitors of NAD+ biosynthesis enzyme
Druggability	Low (0.45)
Clinical Stage	Phase II
Molecular Weight	52 kDa
Gene Type	Protein Coding
Pathways	Akt, Angiogenesis, Autophagy, Cerebrovascular, Cholesterol Metabolism
UniProt ID	Q99714
NCBI Gene ID	10135
Ensembl ID	ENSG00000105835
OMIM	608064
GeneCards	NAMPT
Human Protein Atlas	NAMPT
Associated Diseases	ALS, ALZHEIMER, Aging, Atherosclerosis
Known Drugs/Compounds	nicotinamide, NAMPT positive allosteric modulators
Interactions	CD38, SIRT6, EGR2, PARP1, SIRT1, Rb
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Metabolic NAD+ Salvage Pathway Enhancement Through
KG Connections	608 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NAMPT — AlphaFold A0A7P0TA73 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NAMPT["NAMPT"] -->|"associated"| neurodegeneration["neurodegeneration"]
    NAMPT["NAMPT"] -->|"interacts"| CD38["CD38"]
    NAMPT["NAMPT"] -->|"interacts"| TLR4["TLR4"]
    NAMPT["NAMPT"] -->|"co discussed"| GPX4["GPX4"]
    NAMPT["NAMPT"] -->|"co discussed"| PLA2G6["PLA2G6"]
    NAMPT["NAMPT"] -->|"co discussed"| MMP2["MMP2"]
    CD38_1["CD38"] -->|"interacts"| NAMPT["NAMPT"]
    MMP9["MMP9"] -->|"co discussed"| NAMPT["NAMPT"]
    SLC7A11["SLC7A11"] -->|"co discussed"| NAMPT["NAMPT"]
    AQP4["AQP4"] -->|"co discussed"| NAMPT["NAMPT"]
    style NAMPT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (414)

Target	Relation	Type	Str
NAD salvage pathway	involved_in	pathway	0.90
SIRT1	activates	protein	0.89
Inflammatory Bowel Disease	upregulates	disease	0.85
NAD+ biosynthesis	catalyzes	pathway	0.80
Neutrophilic Inflammation	involved_in	process	0.75
NAD+ metabolism	participates_in	pathway	0.75
Als	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
ferroptosis	participates_in	pathway	0.70
Mitochondrial Function	associated_with	pathway	0.70
Addiction	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Aging	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	expressed_in	disease	0.65
Longevity	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Als	activates	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Aging	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ms	regulates	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
ALS	associated_with	disease	0.65
ALS	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Breast Cancer	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	causes	disease	0.65
Aging	causes	disease	0.65
Stroke	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
Cancer	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65

Incoming (194)

Source	Relation	Type	Str
NAD	metabolizes	gene	0.90
h-cb833ed8	targets_gene	hypothesis	0.90
h-var-159030513d	targets_gene	hypothesis	0.90
h-cb833ed8	targets	hypothesis	0.80
NAMPT positive allosteric modulators	modulates	drug	0.80
CD38	co_mentioned_with	gene	0.80
NAD	implicated_in	gene	0.80
nicotinamide	targets	drug	0.75
DNA	associated_with	gene	0.70
NAD	treats	gene	0.70
CD38	interacts_with	gene	0.64
CD38	regulates	gene	0.60
CD38	associated_with	gene	0.60
CD38	inhibits	gene	0.60
CSF2	regulates	gene	0.60
SIRT6	inhibits	gene	0.60
EGR2	inhibits	gene	0.60
HSPA1A	regulates	gene	0.60
P38	regulates	gene	0.60
CXCL10	regulates	gene	0.60
FGF2	regulates	gene	0.60
PI3K	regulates	gene	0.60
STAT1	regulates	gene	0.60
RB1	therapeutic_target	gene	0.60
EGR2	associated_with	gene	0.60
AKT	regulates	gene	0.60
MTOR	regulates	gene	0.60
FASN	regulates	gene	0.60
CRY1	regulates	gene	0.60
PYCARD	associated_with	gene	0.60
HMOX1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
TLR4	regulates	gene	0.60
ISG15	regulates	gene	0.60
FGF8	regulates	gene	0.60
S100A8	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
PARP1	inhibits	gene	0.60
RPS6	therapeutic_target	gene	0.60
SIRT1	associated_with	gene	0.60
CXCR4	associated_with	gene	0.60
FOXO1	activates	gene	0.60
SIRT1	activates	gene	0.60
CD38	activates	entity	0.60
SIRT1	regulates	gene	0.60
SIRT1	therapeutic_target	gene	0.60
NRF2	associated_with	gene	0.60
TNF	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove	0.592	neurodegeneration	Epigenetic reprogramming in aging neuron

Mentioning Analyses (4)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NAMPT

Understanding Entity Pages

Summary

Wiki Pages (21)

NAMPT Gene

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

NAD+ Precursors for Neurodegeneration

Cellular Senescence in Neurodegeneration

Wallerian Degeneration

Section 103: Sirtuin Pathway and NAD+-Dependent Deacetylases in CBS/PSP

Pathway Diagram

Outgoing (414)

Incoming (194)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Epigenetic reprogramming in aging neurons

Metabolic reprogramming in neurodegenerative disease

Sleep disruption as cause and consequence of neurodegeneration

Senolytic therapy for age-related neurodegeneration

Related Papers (0)

NAMPT

Understanding Entity Pages

Summary

Wiki Pages (21)

NAMPT Gene

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

NAD+ Precursors for Neurodegeneration

Cellular Senescence in Neurodegeneration

Wallerian Degeneration

Section 103: Sirtuin Pathway and NAD+-Dependent Deacetylases in CBS/PSP

Nicotinamide Riboside

NAD+ Metabolism in Neurodegeneration

Calcium Signaling Dysregulation in Alzheimer's Disease

Section 99: Purinergic Signaling and P2X/P2Y Receptors in CBS/PSP

NMNAT3 — Nicotinamide Mononucleotide Adenylyltransferase 3

NNMT Gene

Sirtuin Modulators for Parkinson's Disease

NADK Gene

sirtuin-dysfunction-parkinsons

SIRT1 Signaling Pathway in Alzheimer's Disease

NMNAT1 Gene

Circadian Clock Pathway in Neurodegeneration

NAD Signaling in Neurodegeneration

Sirtuin Pathway Dysfunction Hypothesis in Parkinson's Disease

Circadian Dysregulation in Parkinson's Disease

Pathway Diagram

Outgoing (414)

Incoming (194)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Epigenetic reprogramming in aging neurons

Metabolic reprogramming in neurodegenerative disease

Sleep disruption as cause and consequence of neurodegeneration

Senolytic therapy for age-related neurodegeneration

Related Papers (0)