Autophagy Enhancement via mTOR Inhibition for C9orf72 Dipeptide Repeat Pathology
🧪 Overview
C9orf72 repeat expansions produce toxic dipeptide repeats (DPRs) that impair nucleocytoplasmic transport and autophagy. mTOR inhibition via rapamycin may reduce DPR accumulation. However, rapamycin benefits in Drosophila C9 models did not translate well to mammals, and C9 ASO programs have failed clinically.
🧬 Mechanism
⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — MTOR
No curated PDB or AlphaFold mapping for MTOR yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
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Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for MTOR.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
No resource usage or linked notebooks recorded for this hypothesis yet.
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_synthesizer
| source | v1_phase_c_backfill |
| origin_type | debate_synthesizer |
| _schema_version | 1 |