Labile iron pool expansion amplifies genotype-specific ALS ferroptosis

flowchart TD
A["SOD1 pathology"]
B["TDP-43 pathology"]
C["FUS pathology"]
D["FTL dysfunction"]
E["Impaired iron buffering in motor neurons and glia"]
F["Labile iron pool expansion"]
G["Catalysis of lipid peroxide propagation"]
H["Lipid peroxidation accumulation"]
I["Ferroptosis"]
J["Motor neuron death"]
K["Biomarker-guided patient stratification"]
L["Identification of iron-elevated subgroup"]
M["Iron chelation therapy"]
N["Reduced labile iron"]
O["Neuroprotection"]
A -->|"converges"| D
B -->|"converges"| D
C -->|"converges"| D
D -->|"causes"| E
E -->|"enables"| F
F -->|"drives"| G
G -->|"propagates"| H
H -->|"induces"| I
I -->|"results in"| J
K -->|"identifies"| L
L -->|"enables targeted"| M
M -->|"reduces"| N
N -->|"prevents"| G
M -->|"provides"| O
J -->|"disease progression"| P["ALS phenotype"]
P -->|"clinical outcome"| Q["Neurological deficit"]
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