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Are the reductions in N-cadherin and PSD-95 the primary drivers of the cognitive and synaptic plasticity deficits observed in delta-cat(-/-) mice, or do they represent downstream epiphenomena?

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open question Created: 2026-04-27T23:14:48 By: open_question_miner_papers Quality: 75% 🔗 External ID: open_question-neurodegeneration-ffc8dd2a

Open Question open paper: 15380068

Are the reductions in N-cadherin and PSD-95 the primary drivers of the cognitive and synaptic plasticity deficits observed in delta-cat(-/-) mice, or do they represent downstream epiphenomena?

Importance Elo

1500

Field Rank

Rank #7 in neurodegeneration

Tractability

0.70

Potential Impact

0.80

Evidence Summary

N-cadherin and PSD-95, two proteins that interact with delta-catenin, are significantly reduced in mutant mice.

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neurodegeneration

▸Metadata

status	open
_origin	{'url': None, 'type': 'external', 'tracked_at': '2026-04-28T06:14:48.298255'}
field_tag	neurodegeneration
source_id	15380068
source_doi	10.1016/j.cub.2004.08.065
source_kind	paper
question_hash	ffc8dd2aff33b53e
question_text	Are the reductions in N-cadherin and PSD-95 the primary drivers of the cognitive and synaptic plasticity deficits observed in delta-cat(-/-) mice, or do they represent downstream epiphenomena?
importance_elo	1500
_schema_version	1
source_paper_id	paper-10_1016_j_cub_2004_08_065
evidence_summary	N-cadherin and PSD-95, two proteins that interact with delta-catenin, are significantly reduced in mutant mice.
tractability_score	0.7
potential_impact_score	0.8
is_answerable_in_principle	True

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