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Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls.
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Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls.
Iacob E, Light KC, Tadler SC, Weeks HR, White AT, Hughen RW, Vanhaitsma TA, Bushnell L, Light AR
Abstract
BACKGROUND: Depressive Disorders (DD) are a great financial and social burden. Females display 70% higher rate of depression than males and more than 30% of these patients do not respond to conventional medications. Thus medication-refractory female patients are a large, under-served, group where new biological targets for intervention are greatly needed. METHODS: We used real-time quantitative polymerase chain reaction (qPCR) to evaluate mRNA gene expression from peripheral blood leukocytes for...
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